Early Synaptic Defects in tulp1-/- Mice

Mutations in the photoreceptor-specific tubby-like protein 1 (TULP1) underlie a form of autosomal recessive retinitis pigmentosa. To investigate the role of Tulp1 in the photoreceptor synapse, the authors examined the presynaptic and postsynaptic architecture and retinal function in tulp1(-/-) mice...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 2009-07, Vol.50 (7), p.3074-3083
Hauptverfasser:	Grossman, Gregory H, Pauer, Gayle J. T, Narendra, Umadevi, Peachey, Neal S, Hagstrom, Stephanie A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Cytoskeletal Proteins - metabolism Dendrites - pathology DNA-Binding Proteins - metabolism Electroretinography Eye and associated structures. Visual pathways and centers. Vision Eye Proteins - physiology Female Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Genotype Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - metabolism Neuropeptides - metabolism Ophthalmology Phosphoproteins - metabolism Photoreceptor Cells, Vertebrate - metabolism Photoreceptor Cells, Vertebrate - pathology Presynaptic Terminals - metabolism Presynaptic Terminals - pathology Protein Kinase C-alpha - metabolism Retinal Bipolar Cells - pathology Retinitis Pigmentosa - genetics Retinitis Pigmentosa - metabolism Retinitis Pigmentosa - pathology Rhodopsin - metabolism Synaptic Vesicles - pathology Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!