Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an important role in Aβ aggregation and metabolism, thus metal...

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Veröffentlicht in:	International journal of alzheimer's disease 2011, Vol.2011 (2011), p.1-10
Hauptverfasser:	Ho, Michael, Hoke, David E., Chua, Yee Jia, Li, Qiao-Xin, Culvenor, Janetta G., Masters, Colin L., White, Anthony R., Evin, Geneviève
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-protein Calcium, Dietary Chelating agents Health aspects Magnesium in the body Physiological aspects
Online-Zugang:	Volltext
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