Atorvastatin neutralises the thrombin-induced tissue factor expresion in endothelial cells via geranylgeranyl pyrophosphate

Statins may have beneficial effects in atherogenesis given their antithrombotic properties involving non-lipid mechanisms that modify endothelial function of tissue factor induction by thrombin. In this study, we investigate the effect of atorvastatin on tissue factor (TF) activity in thrombin-stimu...

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Veröffentlicht in:	Cytotechnology (Dordrecht) 2011-01, Vol.63 (1), p.1-5
Hauptverfasser:	Martínez-Sales, Vicenta, Vila, Virtudes, Ferrando, Marcos, Reganon, Edelmiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherogenesis Atorvastatin Biochemistry Biological and medical sciences Biomedicine Biotechnology Brief Report Chemistry Chemistry and Materials Science Coagulation factor VIIa Endothelial cells Experiments Fundamental and applied biological sciences. Psychology Hydrophobicity Kinases Phosphorylation Proteins Rho-associated kinase Signal transduction Statins Subculture Thrombin Tissue factor
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