Regulation of valvular interstitial cell phenotype and function by hyaluronic acid in 2-D and 3-D culture environments

Disruption of the extracellular matrix (ECM) is frequently found in calcific aortic valve disease (CAVD), yet the role of ECM components in valvular interstitial cell (VIC) function and dysfunction remains poorly understood. This study examines the contributions of exogenous and endogenous hyaluroni...

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Veröffentlicht in:	Matrix biology 2011-01, Vol.30 (1), p.70-82
Hauptverfasser:	Rodriguez, Karien J., Piechura, Laura M., Masters, Kristyn S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Valve - pathology Calcinosis Cell Culture Techniques Cells, Cultured Extracellular matrix Extracellular Matrix - metabolism Heart valve calcification Hyaluronan Receptors - metabolism Hyaluronic acid Hyaluronic Acid - metabolism Phenotype Swine Valvular interstitial cells
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