Opposing Actions of Extracellular Signal-regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy

Excessive proliferation and stabilization of the microtubule (MT) array in cardiac myocytes can accompany pathological cardiac hypertrophy, but the molecular control of these changes remains poorly characterized. In this study, we examined MT stabilization in two independent murine models of heart f...

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Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (2), p.1576-1587
Hauptverfasser:	Ng, Dominic C.H., Ng, Ivan H.W., Yeap, Yvonne Y.C., Badrian, Bahareh, Tsoutsman, Tatiana, McMullen, Julie R., Semsarian, Christopher, Bogoyevitch, Marie A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiac Hypertrophy Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomyopathy, Hypertrophic - metabolism Cardiomyopathy, Hypertrophic - pathology Cells, Cultured Cytokine Cytoskeleton Disease Models, Animal ERK Extracellular Signal-Regulated MAP Kinases - metabolism Humans Interleukin-6 - metabolism Male MAP Kinase Signaling System - physiology MAP Kinases (MAPKs) Mice Mice, Inbred Strains Mice, Transgenic Microtubules Microtubules - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Protein Processing, Post-Translational - physiology Rats Rats, Sprague-Dawley RNA, Small Interfering Signal Transduction STAT Transcription Factor STAT3 Transcription Factor - metabolism Tubulin - genetics Tubulin - metabolism
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