Structural and Functional Characterization of a Highly Specific Serpin in the Insect Innate Immunity

The Toll signaling pathway, an essential innate immune response in invertebrates, is mediated via the serine protease cascade. Once activated, the serine proteases are irreversibly inactivated by serine protease inhibitors (serpins). Recently, we identified three serpin-serine protease pairs that ar...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (2), p.1567-1575
Hauptverfasser:	Park, Sun Hee, Jiang, Rui, Piao, Shunfu, Zhang, Bing, Kim, Eun-Hye, Kwon, Hyun-Mi, Jin, Xiao Ling, Lee, Bok Luel, Ha, Nam-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antithrombins - chemistry Antithrombins - metabolism Binding Sites - genetics Binding Sites - immunology Calcium - metabolism Crystal Structure Crystallography Enzyme Activation - immunology Heparin - metabolism Humans Immunity, Innate - physiology Immunology Innate Immunity Molecular Sequence Data Mutagenesis, Site-Directed Protein Structure, Tertiary Serine Protease Serpin Serpins - genetics Serpins - immunology Serpins - metabolism Signal Transduction Signal Transduction - immunology Structure-Activity Relationship Substrate Specificity Tenebrio - enzymology Tenebrio - immunology Tenebrio molitor Toll Receptors Toll-Like Receptors - immunology Toll-Like Receptors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!