Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly

Innate immune receptors detect microbial pathogens and subsequently activate adaptive immune responses to combat pathogen invasion. MyD88 is a key adaptor molecule in both Toll-like receptor (TLR) and IL-1 receptor superfamily signaling pathways. This is illustrated by the fact that human individual...

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Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (2), p.1341-1353
Hauptverfasser:	George, Julie, Motshwene, Precious G., Wang, Hui, Kubarenko, Andriy V., Rautanen, Anna, Mills, Tara C., Hill, Adrian V.S., Gay, Nicholas J., Weber, Alexander N.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins Computer Modeling Crystal Structure Crystallography Death Domain Genetic Polymorphism Genetic Predisposition to Disease Genetic Variation Genotype Humans Immunology Infections - genetics Infections - immunology Infections - metabolism Innate Immunity Interleukin Receptor-associated Kinase (IRAK) Interleukin-1 Receptor-Associated Kinases - immunology Interleukin-1 Receptor-Associated Kinases - metabolism Models, Chemical MyD88 Myeloid Differentiation Factor 88 - chemistry Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Pattern Recognition Receptor Phenotype Polymorphism, Single Nucleotide Protein Structure, Tertiary Signal Transduction - immunology Structure-Activity Relationship
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