Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

Heritable changes in gene expression that are not based upon alterations in the DNA sequence are defined as epigenetics. The most common mechanisms of epigenetic regulation are the methylation of CpG islands within the DNA and the modification of amino acids in the N-terminal histone tails. In the l...

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Veröffentlicht in:	Clinical epigenetics 2010-12, Vol.1 (3-4), p.117-136
Hauptverfasser:	Wagner, Julia M, Hackanson, Björn, Lübbert, Michael, Jung, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Review
Online-Zugang:	Volltext
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