Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism

The interferon‐γ‐induced guanylate‐binding protein 1 (GBP1) belongs to a special class of large GTP‐ binding proteins of 60–100 kDa with unique characteristics. Here we present the structure of human GBP1 in complex with the non‐hydrolysable GTP analogue GppNHp. Basic features of guanine nucleotide...

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Veröffentlicht in:	The EMBO journal 2000-09, Vol.19 (17), p.4555-4564
Hauptverfasser:	Prakash, Balaji, Renault, Louis, Praefcke, Gerrit J.K., Herrmann, Christian, Wittinghofer, Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology crystal structure Crystallography, X-Ray DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism g-Interferon GBP1 GTP GTP Phosphohydrolases - metabolism GTP-binding protein GTP-Binding Proteins - chemistry GTP-Binding Proteins - metabolism GTPase mechanism Guanosine Triphosphate - metabolism guanylate-binding protein 1 Humans Hydrolysis interferon Life Sciences Models, Molecular Ordination Protein Conformation Proteins
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