Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome
Purpose To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis. Methods cTnT levels were measured by the novel hs-cTnT assay at two time points (inclusion and 72 h thereafter) in a subgro...
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| Veröffentlicht in: | Intensive care medicine 2011-01, Vol.37 (1), p.77-85 |
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| creator | Røsjø, Helge Varpula, Marjut Hagve, Tor-Arne Karlsson, Sari Ruokonen, Esko Pettilä, Ville Omland, Torbjørn |
| description | Purpose
To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis.
Methods
cTnT levels were measured by the novel hs-cTnT assay at two time points (inclusion and 72 h thereafter) in a subgroup of patients from the FINNSEPSIS study and associations with clinical outcomes were examined. Results for the hs-cTnT assay were compared to those of the established fourth-generation cTnT assay.
Results
cTnT measured by the fourth-generation and hs-cTnT assay was detectable in 124 (60%) and 207 (100%) patients, respectively, on inclusion in this study. hs-cTnT levels on inclusion correlated with several indices of risk in sepsis, including the simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) scores. The level of hs-cTnT on inclusion was higher in hospital non-survivors (
n
= 47) than survivors (
n
= 160) (median 0.054 [Q1–3, 0.022–0.227] versus 0.035 [0.015–0.111] μg/L,
P
= 0.047), but hs-cTnT level was not an independent predictor of in-hospital mortality. hs-cTnT levels on inclusion were also higher in patients with septic shock during the hospitalization (0.044 [0.024–0.171] versus 0.033 [0.012–0.103] μg/L,
P
= 0.03), while this was not the case for the fourth-generation cTnT assay or NT-proBNP levels.
Conclusions
Circulating hs-cTnT is present in patients with severe sepsis and septic shock, associates with disease severity and survival, but does not add to SAPS II score for prediction of mortality. hs-cTnT measurement could still have a role in sepsis as an early marker of shock. |
| doi_str_mv | 10.1007/s00134-010-2051-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3020309</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A724328481</galeid><sourcerecordid>A724328481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c635t-5dace548bd003a84d1b3d648862c9bae5b57f3e750bf10d5f53a37efbb4c12a23</originalsourceid><addsrcrecordid>eNqFkl1v0zAYhSMEYl3hB3CDLBDiZhn-TNxdIE0VX9Ikbsa15ThvUo_ULrZTbff88Dm0bAwVoUi2FT_nOD45RfGC4FOCcf0uYkwYLzHBJcWClNePihnhjJaEMvm4mGHGackrTo-K4xivMl1XgjwtjiheMJnXs-Ln0gYzDjpZ16OV7Vcogos22a1NNygFv_HOOnSJ8hBhCwHytIk2Iu3aaZmsQXHlzfcz1NqYgm3GZL07QTpGb6xO0KJOm-RDPPmlCTCd5h1KHvkxGb-GZ8WTTg8Rnu_nefHt44fL5efy4uunL8vzi9JUTKRStNqA4LJpMWZa8pY0rK24lBU1i0aDaETdMagFbjqCW9EJplkNXdNwQ6imbF683_luxmYNrQGXgh7UJti1DjfKa6se7ji7Ur3fKoYpZjmzefF2bxD8jxFiUmsbDQyDduDHqKSUeMFztv8nuaykkGLyfPUXeeXH4HIOSrKaV5RXIkOvd1CvB1DWdT5_n5ks1XlN8y_PfiRT5QGqBwf5Mt5BZ_PrB_zpAT4_LaytOSggO4EJPsYA3V12BKupkmpXSZUrqaZKquusefln6HeK3x3MwJs9oKPRQxe0Mzbec0wKXNEqc3THxbzlegj3Qf379Fu7NfrU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>837462465</pqid></control><display><type>article</type><title>Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Røsjø, Helge ; Varpula, Marjut ; Hagve, Tor-Arne ; Karlsson, Sari ; Ruokonen, Esko ; Pettilä, Ville ; Omland, Torbjørn</creator><creatorcontrib>Røsjø, Helge ; Varpula, Marjut ; Hagve, Tor-Arne ; Karlsson, Sari ; Ruokonen, Esko ; Pettilä, Ville ; Omland, Torbjørn ; FINNSEPSIS Study Group ; The FINNSEPSIS Study Group</creatorcontrib><description>Purpose
To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis.
Methods
cTnT levels were measured by the novel hs-cTnT assay at two time points (inclusion and 72 h thereafter) in a subgroup of patients from the FINNSEPSIS study and associations with clinical outcomes were examined. Results for the hs-cTnT assay were compared to those of the established fourth-generation cTnT assay.
Results
cTnT measured by the fourth-generation and hs-cTnT assay was detectable in 124 (60%) and 207 (100%) patients, respectively, on inclusion in this study. hs-cTnT levels on inclusion correlated with several indices of risk in sepsis, including the simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) scores. The level of hs-cTnT on inclusion was higher in hospital non-survivors (
n
= 47) than survivors (
n
= 160) (median 0.054 [Q1–3, 0.022–0.227] versus 0.035 [0.015–0.111] μg/L,
P
= 0.047), but hs-cTnT level was not an independent predictor of in-hospital mortality. hs-cTnT levels on inclusion were also higher in patients with septic shock during the hospitalization (0.044 [0.024–0.171] versus 0.033 [0.012–0.103] μg/L,
P
= 0.03), while this was not the case for the fourth-generation cTnT assay or NT-proBNP levels.
Conclusions
Circulating hs-cTnT is present in patients with severe sepsis and septic shock, associates with disease severity and survival, but does not add to SAPS II score for prediction of mortality. hs-cTnT measurement could still have a role in sepsis as an early marker of shock.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s00134-010-2051-x</identifier><identifier>PMID: 20938765</identifier><identifier>CODEN: ICMED9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthesiology ; Biological and medical sciences ; Biomarkers ; Cardiovascular disease ; Comparative analysis ; Coronary vessels ; Critical Care Medicine ; Emergency and intensive care: infection, septic shock ; Emergency Medicine ; Female ; Finland ; Heart failure ; Hospital Mortality ; Hospitals ; Humans ; Intensive ; Intensive care ; Intensive care medicine ; Male ; Medical prognosis ; Medical research ; Medical sciences ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Mortality ; Original ; Pain Medicine ; Patient outcomes ; Patients ; Pediatrics ; Physiological aspects ; Physiology ; Pneumology/Respiratory System ; Prospective Studies ; Sensitivity and Specificity ; Sepsis ; Sepsis - blood ; Sepsis - mortality ; Septic shock ; Severity of Illness Index ; Shock, Septic - blood ; Shock, Septic - mortality ; Troponin T - blood ; Vein & artery diseases</subject><ispartof>Intensive care medicine, 2011-01, Vol.37 (1), p.77-85</ispartof><rights>The Author(s) 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><rights>Copyright jointly held by Springer and ESICM 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c635t-5dace548bd003a84d1b3d648862c9bae5b57f3e750bf10d5f53a37efbb4c12a23</citedby><cites>FETCH-LOGICAL-c635t-5dace548bd003a84d1b3d648862c9bae5b57f3e750bf10d5f53a37efbb4c12a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00134-010-2051-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00134-010-2051-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23850626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20938765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Røsjø, Helge</creatorcontrib><creatorcontrib>Varpula, Marjut</creatorcontrib><creatorcontrib>Hagve, Tor-Arne</creatorcontrib><creatorcontrib>Karlsson, Sari</creatorcontrib><creatorcontrib>Ruokonen, Esko</creatorcontrib><creatorcontrib>Pettilä, Ville</creatorcontrib><creatorcontrib>Omland, Torbjørn</creatorcontrib><creatorcontrib>FINNSEPSIS Study Group</creatorcontrib><creatorcontrib>The FINNSEPSIS Study Group</creatorcontrib><title>Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><addtitle>Intensive Care Med</addtitle><description>Purpose
To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis.
Methods
cTnT levels were measured by the novel hs-cTnT assay at two time points (inclusion and 72 h thereafter) in a subgroup of patients from the FINNSEPSIS study and associations with clinical outcomes were examined. Results for the hs-cTnT assay were compared to those of the established fourth-generation cTnT assay.
Results
cTnT measured by the fourth-generation and hs-cTnT assay was detectable in 124 (60%) and 207 (100%) patients, respectively, on inclusion in this study. hs-cTnT levels on inclusion correlated with several indices of risk in sepsis, including the simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) scores. The level of hs-cTnT on inclusion was higher in hospital non-survivors (
n
= 47) than survivors (
n
= 160) (median 0.054 [Q1–3, 0.022–0.227] versus 0.035 [0.015–0.111] μg/L,
P
= 0.047), but hs-cTnT level was not an independent predictor of in-hospital mortality. hs-cTnT levels on inclusion were also higher in patients with septic shock during the hospitalization (0.044 [0.024–0.171] versus 0.033 [0.012–0.103] μg/L,
P
= 0.03), while this was not the case for the fourth-generation cTnT assay or NT-proBNP levels.
Conclusions
Circulating hs-cTnT is present in patients with severe sepsis and septic shock, associates with disease severity and survival, but does not add to SAPS II score for prediction of mortality. hs-cTnT measurement could still have a role in sepsis as an early marker of shock.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthesiology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Comparative analysis</subject><subject>Coronary vessels</subject><subject>Critical Care Medicine</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Emergency Medicine</subject><subject>Female</subject><subject>Finland</subject><subject>Heart failure</subject><subject>Hospital Mortality</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intensive</subject><subject>Intensive care</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Original</subject><subject>Pain Medicine</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Pneumology/Respiratory System</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Sepsis</subject><subject>Sepsis - blood</subject><subject>Sepsis - mortality</subject><subject>Septic shock</subject><subject>Severity of Illness Index</subject><subject>Shock, Septic - blood</subject><subject>Shock, Septic - mortality</subject><subject>Troponin T - blood</subject><subject>Vein & artery diseases</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkl1v0zAYhSMEYl3hB3CDLBDiZhn-TNxdIE0VX9Ikbsa15ThvUo_ULrZTbff88Dm0bAwVoUi2FT_nOD45RfGC4FOCcf0uYkwYLzHBJcWClNePihnhjJaEMvm4mGHGackrTo-K4xivMl1XgjwtjiheMJnXs-Ln0gYzDjpZ16OV7Vcogos22a1NNygFv_HOOnSJ8hBhCwHytIk2Iu3aaZmsQXHlzfcz1NqYgm3GZL07QTpGb6xO0KJOm-RDPPmlCTCd5h1KHvkxGb-GZ8WTTg8Rnu_nefHt44fL5efy4uunL8vzi9JUTKRStNqA4LJpMWZa8pY0rK24lBU1i0aDaETdMagFbjqCW9EJplkNXdNwQ6imbF683_luxmYNrQGXgh7UJti1DjfKa6se7ji7Ur3fKoYpZjmzefF2bxD8jxFiUmsbDQyDduDHqKSUeMFztv8nuaykkGLyfPUXeeXH4HIOSrKaV5RXIkOvd1CvB1DWdT5_n5ks1XlN8y_PfiRT5QGqBwf5Mt5BZ_PrB_zpAT4_LaytOSggO4EJPsYA3V12BKupkmpXSZUrqaZKquusefln6HeK3x3MwJs9oKPRQxe0Mzbec0wKXNEqc3THxbzlegj3Qf379Fu7NfrU</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Røsjø, Helge</creator><creator>Varpula, Marjut</creator><creator>Hagve, Tor-Arne</creator><creator>Karlsson, Sari</creator><creator>Ruokonen, Esko</creator><creator>Pettilä, Ville</creator><creator>Omland, Torbjørn</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QL</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome</title><author>Røsjø, Helge ; Varpula, Marjut ; Hagve, Tor-Arne ; Karlsson, Sari ; Ruokonen, Esko ; Pettilä, Ville ; Omland, Torbjørn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c635t-5dace548bd003a84d1b3d648862c9bae5b57f3e750bf10d5f53a37efbb4c12a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthesiology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Comparative analysis</topic><topic>Coronary vessels</topic><topic>Critical Care Medicine</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Emergency Medicine</topic><topic>Female</topic><topic>Finland</topic><topic>Heart failure</topic><topic>Hospital Mortality</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Intensive</topic><topic>Intensive care</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Original</topic><topic>Pain Medicine</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Pneumology/Respiratory System</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Sepsis</topic><topic>Sepsis - blood</topic><topic>Sepsis - mortality</topic><topic>Septic shock</topic><topic>Severity of Illness Index</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - mortality</topic><topic>Troponin T - blood</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Røsjø, Helge</creatorcontrib><creatorcontrib>Varpula, Marjut</creatorcontrib><creatorcontrib>Hagve, Tor-Arne</creatorcontrib><creatorcontrib>Karlsson, Sari</creatorcontrib><creatorcontrib>Ruokonen, Esko</creatorcontrib><creatorcontrib>Pettilä, Ville</creatorcontrib><creatorcontrib>Omland, Torbjørn</creatorcontrib><creatorcontrib>FINNSEPSIS Study Group</creatorcontrib><creatorcontrib>The FINNSEPSIS Study Group</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Røsjø, Helge</au><au>Varpula, Marjut</au><au>Hagve, Tor-Arne</au><au>Karlsson, Sari</au><au>Ruokonen, Esko</au><au>Pettilä, Ville</au><au>Omland, Torbjørn</au><aucorp>FINNSEPSIS Study Group</aucorp><aucorp>The FINNSEPSIS Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome</atitle><jtitle>Intensive care medicine</jtitle><stitle>Intensive Care Med</stitle><addtitle>Intensive Care Med</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>37</volume><issue>1</issue><spage>77</spage><epage>85</epage><pages>77-85</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>Purpose
To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis.
Methods
cTnT levels were measured by the novel hs-cTnT assay at two time points (inclusion and 72 h thereafter) in a subgroup of patients from the FINNSEPSIS study and associations with clinical outcomes were examined. Results for the hs-cTnT assay were compared to those of the established fourth-generation cTnT assay.
Results
cTnT measured by the fourth-generation and hs-cTnT assay was detectable in 124 (60%) and 207 (100%) patients, respectively, on inclusion in this study. hs-cTnT levels on inclusion correlated with several indices of risk in sepsis, including the simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) scores. The level of hs-cTnT on inclusion was higher in hospital non-survivors (
n
= 47) than survivors (
n
= 160) (median 0.054 [Q1–3, 0.022–0.227] versus 0.035 [0.015–0.111] μg/L,
P
= 0.047), but hs-cTnT level was not an independent predictor of in-hospital mortality. hs-cTnT levels on inclusion were also higher in patients with septic shock during the hospitalization (0.044 [0.024–0.171] versus 0.033 [0.012–0.103] μg/L,
P
= 0.03), while this was not the case for the fourth-generation cTnT assay or NT-proBNP levels.
Conclusions
Circulating hs-cTnT is present in patients with severe sepsis and septic shock, associates with disease severity and survival, but does not add to SAPS II score for prediction of mortality. hs-cTnT measurement could still have a role in sepsis as an early marker of shock.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20938765</pmid><doi>10.1007/s00134-010-2051-x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0342-4642 |
| ispartof | Intensive care medicine, 2011-01, Vol.37 (1), p.77-85 |
| issn | 0342-4642 1432-1238 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3020309 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Biological and medical sciences Biomarkers Cardiovascular disease Comparative analysis Coronary vessels Critical Care Medicine Emergency and intensive care: infection, septic shock Emergency Medicine Female Finland Heart failure Hospital Mortality Hospitals Humans Intensive Intensive care Intensive care medicine Male Medical prognosis Medical research Medical sciences Medicine Medicine & Public Health Medicine, Experimental Middle Aged Mortality Original Pain Medicine Patient outcomes Patients Pediatrics Physiological aspects Physiology Pneumology/Respiratory System Prospective Studies Sensitivity and Specificity Sepsis Sepsis - blood Sepsis - mortality Septic shock Severity of Illness Index Shock, Septic - blood Shock, Septic - mortality Troponin T - blood Vein & artery diseases |
| title | Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome |
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