miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN -amplified neuroblastoma

The characterization of miR-380-5p–driven p53 repression provides a new mechanism for downmodulation of stress-induced antiproliferative responses in wild-type p53 contexts, including embryonic stem cells and neuroblastoma tumors. miR-380-5p potentiates Ras-induced mammary gland tumorigenesis and is...

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Veröffentlicht in:	Nature medicine 2010-10, Vol.16 (10), p.1134-1140
Hauptverfasser:	Swarbrick, Alexander, Goga, Andrei, Woods, Susan L, Shaw, Alexander, Balakrishnan, Asha, Phua, Yuwei, Nguyen, Akira, Chanthery, Yvan, Lim, Lionel, Ashton, Lesley J, Judson, Robert L, Huskey, Noelle, Blelloch, Robert, Haber, Michelle, Norris, Murray D, Lengyel, Peter, Hackett, Christopher S, Preiss, Thomas, Chetcuti, Albert, Sullivan, Christopher S, Marcusson, Eric G, Weiss, William, L'Etoile, Noelle
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 631/378/1689/1690 631/61/51/391 Animals Apoptosis Binding Sites Biomedical and Life Sciences Biomedicine Cancer Cancer cells Cancer Research Cellular biology Development and progression DNA Damage Female Gene Amplification Gene expression Genetic aspects Humans Inactivation Infectious Diseases Metabolic Diseases Mice Mice, Inbred BALB C Mice, Transgenic MicroRNAs - physiology Molecular Medicine N-Myc Proto-Oncogene Protein Neuroblastoma Neuroblastoma - genetics Neuroblastoma - pathology Neurosciences Nuclear Proteins - genetics Oncogene Proteins - genetics Oncogenes Patient outcomes Physiological aspects Properties Stem cells Tumor suppressor genes Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - physiology Tumors
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