Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure

Abstract The AE3 Cl− /HCO3− exchanger is abundantly expressed in the sarcolemma of cardiomyocytes, where it mediates Cl− -uptake and HCO3− -extrusion. Inhibition of AE3-mediated Cl− /HCO3− exchange has been suggested to protect against cardiac hypertrophy; however, other studies indicate that AE3 mi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular and cellular cardiology 2011-01, Vol.50 (1), p.137-146
Hauptverfasser:	Al Moamen, Nabeel J, Prasad, Vikram, Bodi, Ilona, Miller, Marian L, Neiman, Michelle L, Lasko, Valerie M, Alper, Seth L, Wieczorek, David F, Lorenz, John N, Shull, Gary E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiporters - metabolism Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cardiomyopathy, Hypertrophic - genetics Cardiomyopathy, Hypertrophic - metabolism Cardiovascular Cation Transport Proteins Congestive heart failure Decompensated Female Force frequency response Heart Failure - genetics Heart Failure - metabolism Immunoblotting Male Mice Mice, Mutant Strains Mice, Transgenic Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Pacing Phosphoprotein Phosphatases - metabolism Phosphorylation Slc4a3 Sodium-Hydrogen Exchanger 1 Sodium-Hydrogen Exchangers
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!