Wind-up of stretch reflexes as a measure of spasticity in chronic spinalized rats: The effects of passive exercise and modafinil

Spasticity is a common disorder following spinal cord injury that can impair function and quality of life. While a number of mechanisms are thought to play a role in spasticity, the role of motoneuron persistent inward currents (PICs) is emerging as pivotal. The presence of PICs can be evidenced by...

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Veröffentlicht in:	Experimental neurology 2011-01, Vol.227 (1), p.104-109
Hauptverfasser:	Garrison, M. Kevin, Yates, Charlotte C., Reese, Nancy B., Skinner, Robert D., Garcia-Rill, Edgar
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Benzhydryl Compounds - therapeutic use Biological and medical sciences Chronic Disease Disease Models, Animal Electromyography - methods Exercise Female H-reflex H-Reflex - drug effects H-Reflex - physiology Medical sciences Modafinil Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Muscle Spasticity - diagnosis Muscle Spasticity - drug therapy Muscle Spasticity - etiology Muscle Spasticity - rehabilitation Muscle, Skeletal - drug effects Muscle, Skeletal - physiopathology Neurology Neuroprotective Agents - therapeutic use Physical Conditioning, Animal - methods Random Allocation Rats Rats, Sprague-Dawley Reflex, Stretch - drug effects Reflex, Stretch - physiology Severity of Illness Index Spasticity Spinal Cord Injuries - complications Spinal Cord Injuries - rehabilitation Spinal cord injury Stretch reflex Time Factors Torque
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