Efavirenz concentrations in CSF exceed IC50 for wild-type HIV

HIV-associated neurocognitive disorders remain common despite use of potent antiretroviral therapy (ART). Ongoing viral replication due to poor distribution of antivirals into the CNS may increase risk for HIV-associated neurocognitive disorders. This study's objective was to determine penetrat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antimicrobial chemotherapy 2011-02, Vol.66 (2), p.354-357
Hauptverfasser:	BEST, Brookie M, KOOPMANS, Peter P, SIMPSON, David M, HAUBRICH, Richard, ELLIS, Ronald, GRANT, Igor, LETENDRE, Scott L, CAPPARELLI, Edmund V, ROSSI, Steven S, CLIFFORD, David B, COLLIER, Ann C, GELMAN, Benjamin B, MBEO, Gilbert, MCCUTCHAN, J. Allen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Anti-HIV Agents - blood Anti-HIV Agents - cerebrospinal fluid Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents antiretroviral therapy Antiviral agents Benzoxazines - blood Benzoxazines - cerebrospinal fluid Benzoxazines - therapeutic use Biological and medical sciences Brain Central nervous system Cerebrospinal fluid Chromatography, High Pressure Liquid Cognition Drugs Efavirenz Female High-performance liquid chromatography HIV Infections - cerebrospinal fluid HIV Infections - complications HIV Infections - drug therapy HIV Infections - virology Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Inhibitory Concentration 50 Male Mass spectroscopy Medical sciences Middle Aged Nervous System Diseases - cerebrospinal fluid Nervous System Diseases - drug therapy Nervous System Diseases - virology Neurological diseases Original Research Pharmacology. Drug treatments Random Allocation Replication Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!