Methaneseleninic Acid Is a Substrate for Truncated Mammalian Thioredoxin Reductase: Implications for the Catalytic Mechanism and Redox Signaling

Mammalian thioredoxin reductase is a homodimeric pyridine nucleotide disulfide oxidoreductase that contains the rare amino acid selenocysteine (Sec) on a C-terminal extension. We previously have shown that a truncated version of mouse mitochondrial thioredoxin reductase missing this C-terminal tail...

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Veröffentlicht in:	Biochemistry (Easton) 2010-12, Vol.49 (48), p.10329-10338
Hauptverfasser:	Snider, Gregg, Grout, Leah, Ruggles, Erik L, Hondal, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocatalysis Dithionitrobenzoic Acid - metabolism Enzyme Stability Hydrogen-Ion Concentration Kinetics Mice Organoselenium Compounds - metabolism Oxidation-Reduction Sequence Deletion Thioredoxin-Disulfide Reductase - chemistry Thioredoxin-Disulfide Reductase - genetics Thioredoxin-Disulfide Reductase - metabolism
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