E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity

Oligomers of 40- or 42-mer amyloid β-protein (Aβ40, Aβ42) cause cognitive decline and synaptic dysfunction in Alzheimer's disease. We proposed the importance of a turn at Glu22 and Asp23 of Aβ42 to induce its neurotoxicity through the formation of radicals. Recently, a novel deletion mutant at...

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Veröffentlicht in:	International journal of alzheimer's disease 2011, Vol.2011 (2011), p.1-8
Hauptverfasser:	Suzuki, Takayuki, Murakami, Kazuma, Izuo, Naotaka, Kume, Toshiaki, Akaike, Akinori, Nagata, Tetsu, Nishizaki, Tomoyuki, Tomiyama, Takami, Takuma, Hiroshi, Mori, Hiroshi, Irie, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-protein Gene mutations Genetic aspects Health aspects Physiological aspects Risk factors
Online-Zugang:	Volltext
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