Review: Contribution of transgenic models to understanding human prion disease

J. D. F. Wadsworth, E. A. Asante and J. Collinge (2010) Neuropathology and Applied Neurobiology36, 576–597 Contribution of transgenic models to understanding human prion disease Transgenic mice expressing human prion protein in the absence of endogenous mouse prion protein faithfully replicate human...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2010-12, Vol.36 (7), p.576-597
Hauptverfasser:	Wadsworth, J. D. F., Asante, E. A., Collinge, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Animals, Genetically Modified - physiology Biological and medical sciences Bovine spongiform encephalopathy Cattle Creutzfeldt-Jakob disease Decontamination Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal fatal familial insomnia Gerstmann-Sträussler-Scheinker disease Humans kuru Medical sciences Mice Mice, Transgenic Nervous system Neurodegeneration Neurology Neuropathology Neurotransmission Phenotype prion Prion Diseases - genetics Prion Diseases - pathology Prion protein Prions - classification Prions - genetics Prions - physiology Review Reviews Transgenic mice variant Creutzfeldt-Jakob disease
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