Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

The insulin/insulin growth factor (IGF) signaling (IIS) pathway is a key regulator of aging of worms, flies, mice, and likely humans. Delayed aging by IIS reduction protects the nematode C. elegans from toxicity associated with the aggregation of the Alzheimer's disease-linked human peptide, Aβ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2009-12, Vol.139 (6), p.1157-1169
Hauptverfasser:	Cohen, Ehud, Paulsson, Johan F., Blinder, Pablo, Burstyn-Cohen, Tal, Du, Deguo, Estepa, Gabriela, Adame, Anthony, Pham, Hang M., Holzenberger, Martin, Kelly, Jeffery W., Masliah, Eliezer, Dillin, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Amyloid beta-Peptides - metabolism Animals Humans HUMDISEASE Insulin-Like Growth Factor I - metabolism Longevity Male Mice Mice, Transgenic Presenilin-1 - genetics Presenilin-1 - metabolism PROTEINS Receptor, IGF Type 1 - metabolism Signal Transduction SIGNALING
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!