Outcomes in patients treated by laparoscopic resection of rectal carcinoma after neoadjuvant therapy for rectal cancer
We analyzed the effect of neoadjuvant chemo radiation on feasibility and outcomes in rectal cancer patients undergoing laparoscopic resection of the rectum. This was a retrospective analysis of a consecutive series of laparoscopic resections for rectal cancer from 1998 to 2004 (N=60). Eight patients...
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| Veröffentlicht in: | Journal of the Society of Laparoendoscopic Surgeons 2007-04, Vol.11 (2), p.204-207 |
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| creator | Rezvani, Masoud Franko, Jan Fassler, Steven A Harper, Steven G Nejman, Joseph H Zebley, D Mark |
| description | We analyzed the effect of neoadjuvant chemo radiation on feasibility and outcomes in rectal cancer patients undergoing laparoscopic resection of the rectum.
This was a retrospective analysis of a consecutive series of laparoscopic resections for rectal cancer from 1998 to 2004 (N=60).
Eight patients received preoperative chemoradiation therapy (neoadjuvant group) for rectal cancer and 52 patients did not (primary surgical group). The conversion rate was higher in the neoadjuvant group, but this did not reach statistical significance (3/8, 37% in the neoadjuvant group vs. 7/52, 13% in the primary surgical group, P=0.12). Operative time was longer in the neoadjuvant group (170+/-60 vs 228+/-70 min, P=0.03). Complication rates (3/52, 5.7% in the primary surgical vs. 0% in the neoadjuvant group, P=1.0), and a median number of resected lymph nodes (14.5 in the primary surgical vs. 16.0 in the neoadjuvant group, P=0.81) were similar between groups.
Laparoscopic resection of rectal cancer in patients after preoperative chemoradiation treatment seems to be associated with a higher conversion rate and a longer duration of surgery. No change in mortality and morbidity was detected. We encourage further investigation of laparoscopic rectal surgery for treatment of rectal cancer. |
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This was a retrospective analysis of a consecutive series of laparoscopic resections for rectal cancer from 1998 to 2004 (N=60).
Eight patients received preoperative chemoradiation therapy (neoadjuvant group) for rectal cancer and 52 patients did not (primary surgical group). The conversion rate was higher in the neoadjuvant group, but this did not reach statistical significance (3/8, 37% in the neoadjuvant group vs. 7/52, 13% in the primary surgical group, P=0.12). Operative time was longer in the neoadjuvant group (170+/-60 vs 228+/-70 min, P=0.03). Complication rates (3/52, 5.7% in the primary surgical vs. 0% in the neoadjuvant group, P=1.0), and a median number of resected lymph nodes (14.5 in the primary surgical vs. 16.0 in the neoadjuvant group, P=0.81) were similar between groups.
Laparoscopic resection of rectal cancer in patients after preoperative chemoradiation treatment seems to be associated with a higher conversion rate and a longer duration of surgery. No change in mortality and morbidity was detected. We encourage further investigation of laparoscopic rectal surgery for treatment of rectal cancer.</description><identifier>ISSN: 1086-8089</identifier><identifier>EISSN: 1938-3797</identifier><identifier>PMID: 17761081</identifier><language>eng</language><publisher>United States: Society of Laparoendoscopic Surgeons</publisher><subject>Aged ; Carcinoma - drug therapy ; Carcinoma - radiotherapy ; Carcinoma - surgery ; Follow-Up Studies ; Humans ; Laparoscopy - methods ; Neoadjuvant Therapy ; Rectal Neoplasms - drug therapy ; Rectal Neoplasms - radiotherapy ; Rectal Neoplasms - surgery ; Retrospective Studies ; Scientific Papers ; Treatment Outcome</subject><ispartof>Journal of the Society of Laparoendoscopic Surgeons, 2007-04, Vol.11 (2), p.204-207</ispartof><rights>2007 by JSLS, Journal of the Society of Laparoendoscopic Surgeons. 2007 Society of Laparoendoscopic Surgeons, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015728/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015728/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17761081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rezvani, Masoud</creatorcontrib><creatorcontrib>Franko, Jan</creatorcontrib><creatorcontrib>Fassler, Steven A</creatorcontrib><creatorcontrib>Harper, Steven G</creatorcontrib><creatorcontrib>Nejman, Joseph H</creatorcontrib><creatorcontrib>Zebley, D Mark</creatorcontrib><title>Outcomes in patients treated by laparoscopic resection of rectal carcinoma after neoadjuvant therapy for rectal cancer</title><title>Journal of the Society of Laparoendoscopic Surgeons</title><addtitle>JSLS</addtitle><description>We analyzed the effect of neoadjuvant chemo radiation on feasibility and outcomes in rectal cancer patients undergoing laparoscopic resection of the rectum.
This was a retrospective analysis of a consecutive series of laparoscopic resections for rectal cancer from 1998 to 2004 (N=60).
Eight patients received preoperative chemoradiation therapy (neoadjuvant group) for rectal cancer and 52 patients did not (primary surgical group). The conversion rate was higher in the neoadjuvant group, but this did not reach statistical significance (3/8, 37% in the neoadjuvant group vs. 7/52, 13% in the primary surgical group, P=0.12). Operative time was longer in the neoadjuvant group (170+/-60 vs 228+/-70 min, P=0.03). Complication rates (3/52, 5.7% in the primary surgical vs. 0% in the neoadjuvant group, P=1.0), and a median number of resected lymph nodes (14.5 in the primary surgical vs. 16.0 in the neoadjuvant group, P=0.81) were similar between groups.
Laparoscopic resection of rectal cancer in patients after preoperative chemoradiation treatment seems to be associated with a higher conversion rate and a longer duration of surgery. No change in mortality and morbidity was detected. We encourage further investigation of laparoscopic rectal surgery for treatment of rectal cancer.</description><subject>Aged</subject><subject>Carcinoma - drug therapy</subject><subject>Carcinoma - radiotherapy</subject><subject>Carcinoma - surgery</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Laparoscopy - methods</subject><subject>Neoadjuvant Therapy</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>Scientific Papers</subject><subject>Treatment Outcome</subject><issn>1086-8089</issn><issn>1938-3797</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF9LwzAUxYsobk6_guTJt0KTtE3yIshQJwz2os_lNr11GW1Sk3Swb2-H89_TvZdz-B3OPUvmVHGZcqHE-bRnskxlJtUsuQphl2V5wbLiMplRIcpJpPNkvxmjdj0GYiwZIBq0MZDoESI2pD6QDgbwLmg3GE08BtTROEtcOx06Qkc0eG2s64FAG9ETiw6a3bgHG0ncoofhQFrnf-1Wo79OLlroAt6c5iJ5e3p8Xa7S9eb5ZfmwTgcqVEwV5TkVba2VqqWkJW_rgkHOAIEVQtcSZJ4zJVBzRhUtkGUNV6BLbDWjpeSL5P6LO4x1j42e2nnoqsGbHvyhcmCq_4o12-rd7Sue0UKwI-DuBPDuY8QQq94EjV0HU88xVKVkjPHiaLz9m_QT8f1q_gm9cX9n</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Rezvani, Masoud</creator><creator>Franko, Jan</creator><creator>Fassler, Steven A</creator><creator>Harper, Steven G</creator><creator>Nejman, Joseph H</creator><creator>Zebley, D Mark</creator><general>Society of Laparoendoscopic Surgeons</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200704</creationdate><title>Outcomes in patients treated by laparoscopic resection of rectal carcinoma after neoadjuvant therapy for rectal cancer</title><author>Rezvani, Masoud ; Franko, Jan ; Fassler, Steven A ; Harper, Steven G ; Nejman, Joseph H ; Zebley, D Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p179t-913417fbc99b88163fb52a42aea257cb8a844297ec321915e20d39ac6efc21683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Carcinoma - drug therapy</topic><topic>Carcinoma - radiotherapy</topic><topic>Carcinoma - surgery</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Laparoscopy - methods</topic><topic>Neoadjuvant Therapy</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Rectal Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>Scientific Papers</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rezvani, Masoud</creatorcontrib><creatorcontrib>Franko, Jan</creatorcontrib><creatorcontrib>Fassler, Steven A</creatorcontrib><creatorcontrib>Harper, Steven G</creatorcontrib><creatorcontrib>Nejman, Joseph H</creatorcontrib><creatorcontrib>Zebley, D Mark</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Society of Laparoendoscopic Surgeons</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezvani, Masoud</au><au>Franko, Jan</au><au>Fassler, Steven A</au><au>Harper, Steven G</au><au>Nejman, Joseph H</au><au>Zebley, D Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes in patients treated by laparoscopic resection of rectal carcinoma after neoadjuvant therapy for rectal cancer</atitle><jtitle>Journal of the Society of Laparoendoscopic Surgeons</jtitle><addtitle>JSLS</addtitle><date>2007-04</date><risdate>2007</risdate><volume>11</volume><issue>2</issue><spage>204</spage><epage>207</epage><pages>204-207</pages><issn>1086-8089</issn><eissn>1938-3797</eissn><abstract>We analyzed the effect of neoadjuvant chemo radiation on feasibility and outcomes in rectal cancer patients undergoing laparoscopic resection of the rectum.
This was a retrospective analysis of a consecutive series of laparoscopic resections for rectal cancer from 1998 to 2004 (N=60).
Eight patients received preoperative chemoradiation therapy (neoadjuvant group) for rectal cancer and 52 patients did not (primary surgical group). The conversion rate was higher in the neoadjuvant group, but this did not reach statistical significance (3/8, 37% in the neoadjuvant group vs. 7/52, 13% in the primary surgical group, P=0.12). Operative time was longer in the neoadjuvant group (170+/-60 vs 228+/-70 min, P=0.03). Complication rates (3/52, 5.7% in the primary surgical vs. 0% in the neoadjuvant group, P=1.0), and a median number of resected lymph nodes (14.5 in the primary surgical vs. 16.0 in the neoadjuvant group, P=0.81) were similar between groups.
Laparoscopic resection of rectal cancer in patients after preoperative chemoradiation treatment seems to be associated with a higher conversion rate and a longer duration of surgery. No change in mortality and morbidity was detected. We encourage further investigation of laparoscopic rectal surgery for treatment of rectal cancer.</abstract><cop>United States</cop><pub>Society of Laparoendoscopic Surgeons</pub><pmid>17761081</pmid><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aged Carcinoma - drug therapy Carcinoma - radiotherapy Carcinoma - surgery Follow-Up Studies Humans Laparoscopy - methods Neoadjuvant Therapy Rectal Neoplasms - drug therapy Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Retrospective Studies Scientific Papers Treatment Outcome |
| title | Outcomes in patients treated by laparoscopic resection of rectal carcinoma after neoadjuvant therapy for rectal cancer |
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