Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency‐Associated Genes

We report here that butyrate, a naturally occurring fatty acid commonly used as a nutritional supplement and differentiation agent, greatly enhances the efficiency of induced pluripotent stem (iPS) cell derivation from human adult or fetal fibroblasts. After transient butyrate treatment, the iPS cel...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2010-04, Vol.28 (4), p.713-720
Hauptverfasser:	Mali, Prashant, Chou, Bin‐Kuan, Yen, Jonathan, Ye, Zhaohui, Zou, Jizhong, Dowey, Sarah, Brodsky, Robert A., Ohm, Joyce E., Yu, Wayne, Baylin, Stephen B., Yusa, Kosuke, Bradley, Allan, Meyers, David J., Mukherjee, Chandrani, Cole, Philip A., Cheng, Linzhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Butyrates - pharmacology Cell Culture Techniques - methods Cells, Cultured Cellular Senescence DNA Transposable Elements Epigenesis, Genetic - drug effects Genetic Vectors - genetics Humans Induced pluripotent stem cells Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Kruppel-Like Factor 4 piggyBac DNA transposition Reprogramming Sequence Alignment Sickle cell disease Sodium butyrate
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