Combined analysis of HPV DNA, p16, p21 and p53 to predict prognosis in patients with stage IV hypopharyngeal carcinoma

Purpose We examined p16, p21 and p53 expression in combination with the presence of human papillomavirus (HPV) DNA as molecular markers to predict survival in patients with stage IV hypopharyngeal squamous cell carcinoma (HSCC). Methods Paraffin-embedded tumours from HSCC patients (n = 75) were eval...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2011-01, Vol.137 (1), p.173-181
Hauptverfasser:	Ernoux-Neufcoeur, Perle, Arafa, Mohammad, Decaestecker, Christine, Duray, Anaëlle, Remmelink, Myriam, Leroy, Xavier, Herfs, Michael, Somja, Joan, Depuydt, Christophe E, Delvenne, Philippe, Saussez, Sven
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Biological and medical sciences Biomarkers Cancer Research carcinoma Carcinoma - diagnosis Carcinoma - pathology Cell survival Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA, Viral - analysis Female Gene expression Genotype & phenotype Genotyping Head & neck cancer Hematology Human health sciences Human papillomavirus Humans Hypopharynx Immunohistochemistry Immunologie & maladie infectieuse Immunology & infectious disease Infectious diseases Internal Medicine Male Medical prognosis Medical sciences Medicine Medicine & Public Health Middle Aged Neoplasm Proteins - metabolism Neoplasm Staging Oncologie Oncology Original Paper Oropharyngeal Neoplasms - diagnosis Oropharyngeal Neoplasms - pathology Otorhinolaryngology. Stomatology p53 protein Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - pathology Papillomavirus Infections - virology PCR Pharmacology. Drug treatments Polymerase chain reaction Prognosis Risk factors Risk groups Sciences de la santé humaine squamous cell carcinoma Survival Tumor Suppressor Protein p53 - metabolism Tumors Typing Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Viral diseases
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