role for the B-cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide

Systemic lupus erythematosus (SLE) is an autoimmune disease that involves dysregulation of B and T cells. A tolerogenic peptide, designated hCDR1, ameliorates disease manifestations in SLE-afflicted mice. In the present study, the effect of treatment with hCDR1 on the CD74/macrophage migration inhib...

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Veröffentlicht in:	Immunology 2011, Vol.132 (1), p.87-95
Hauptverfasser:	Lapter, Smadar, Ben-David, Hava, Sharabi, Amir, Zinger, Heidy, Telerman, Alona, Gordin, Maya, Leng, Lin, Bucala, Richard, Shachar, Idit, Mozes, Edna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, B-Lymphocyte - biosynthesis Antigens, Differentiation, B-Lymphocyte - genetics Antigens, Differentiation, B-Lymphocyte - immunology apoptosis Apoptosis - drug effects Apoptosis - immunology Autoantigens - chemistry Autoantigens - immunology Autoimmune diseases B cells B-Lymphocytes - drug effects B-Lymphocytes - immunology Histocompatibility Antigens Class II - biosynthesis Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Humans Immune system Immunomodulation Indexing in process Intramolecular Oxidoreductases - biosynthesis Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - immunology Lupus Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology lupus/systemic lupus erythematosus Macrophage Migration-Inhibitory Factors - biosynthesis Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - immunology Mice Mice, Inbred NZB Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - immunology Original peptide immunotherapy Peptides - chemistry Peptides - immunology Peptides - pharmacology signalling
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