Down-Regulation of Synaptic GluN2B Subunit-Containing N-methyl-d-aspartate Receptors: A Physiological Brake on CA1 Neuron α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Hyperexcitability during Benzodiazepine Withdrawal

A significant link was previously established between benzodiazepine withdrawal anxiety and a progressive increase in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) potentiation in hippocampal CA1 neurons from rats withdrawn up to 2 days from 1-week oral administration of the...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2011-01, Vol.336 (1), p.265-273
Hauptverfasser:	Shen, Guofu, Tietz, Elizabeth I.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Animals Benzodiazepines - toxicity CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - physiology Down-Regulation - drug effects Down-Regulation - physiology Male Neurons - drug effects Neurons - physiology Neuropharmacology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Substance Withdrawal Syndrome - metabolism Synapses - drug effects Synapses - metabolism
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