Organizing signal transduction through A-kinase anchoring proteins (AKAPs)
A fundamental role for protein-protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is o...
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| Veröffentlicht in: | The FEBS journal 2010-11, Vol.277 (21), p.4370-4375 |
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| container_title | The FEBS journal |
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| creator | Logue, Jeremy S Scott, John D |
| description | A fundamental role for protein-protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is organized by A-kinase anchoring proteins. This family of proteins assembles enzyme complexes containing the cAMP-dependent protein kinase, phosphoprotein phosphatases, phosphodiesterases and other signaling effectors to optimize cellular responses to cAMP and other second messengers. Selected A-kinase anchoring protein signaling complexes are highlighted in this minireview. |
| doi_str_mv | 10.1111/j.1742-4658.2010.07866.x |
| format | Article |
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| subjects | A Kinase Anchor Proteins - metabolism AKAP Animals Biochemistry cAMP Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism enzyme complexes Enzymes Humans Kinases Models, Biological Phosphoprotein Phosphatases - metabolism Phosphoric Diester Hydrolases - metabolism Protein Binding Proteins Signal Transduction |
| title | Organizing signal transduction through A-kinase anchoring proteins (AKAPs) |
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