A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

The safe and effective delivery of RNA interference (RNAi) therapeutics remains an important challenge for clinical development. The diversity of current delivery materials remains limited, in part because of their slow, multi-step syntheses. Here we describe a new class of lipid-like delivery molec...

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Veröffentlicht in:	Nature biotechnology 2008-05, Vol.26 (5), p.561-569
Hauptverfasser:	Akinc, Akin, Zumbuehl, Andreas, Goldberg, Michael, Leshchiner, Elizaveta S, Busini, Valentina, Hossain, Naushad, Bacallado, Sergio A, Nguyen, David N, Fuller, Jason, Alvarez, Rene, Borodovsky, Anna, Borland, Todd, Constien, Rainer, de Fougerolles, Antonin, Dorkin, J Robert, Narayanannair Jayaprakash, K, Jayaraman, Muthusamy, John, Matthias, Koteliansky, Victor, Manoharan, Muthiah, Nechev, Lubomir, Qin, June, Racie, Timothy, Raitcheva, Denitza, Rajeev, Kallanthottathil G, Sah, Dinah W Y, Soutschek, Jürgen, Toudjarska, Ivanka, Vornlocher, Hans-Peter, Zimmermann, Tracy S, Langer, Robert, Anderson, Daniel G
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal models Biochemistry Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Chemical synthesis Combinatorial Chemistry Techniques - methods Drug Carriers - chemistry Drug Design Evaluation Fundamental and applied biological sciences. Psychology General pharmacology Genetic transcription Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Life Sciences Lipid research Lipids Lipids - chemistry Medical sciences Miscellaneous Molecular biology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Primates Properties Ribonucleic acid RNA RNA - administration & dosage RNA - genetics RNA Interference
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