Simvastatin prevents inflammation‐induced aortic stiffening and endothelial dysfunction

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Both acute and chronic inflammation are associated with aortic stiffening and endothelial dysfunction. • Statins have been shown to reduce inflammation and arterial stiffening and to improve endothelial function in patients with chronic inflammation. • In a...

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Veröffentlicht in:	British journal of clinical pharmacology 2010-12, Vol.70 (6), p.799-806
Hauptverfasser:	Wallace, Sharon M. L., Mäki‐Petäjä, Kaisa M., Cheriyan, Joseph, Davidson, Edward H., Cherry, Lynne, McEniery, Carmel M., Sattar, Naveed, Wilkinson, Ian B., Kharbanda, Rajesh K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aorta - drug effects Aorta - physiopathology Aortic Diseases - etiology Aortic Diseases - physiopathology Aortic Diseases - prevention & control aortic stiffness apolipoprotein A‐I Biological and medical sciences Blood Flow Velocity - drug effects Double-Blind Method endothelial dysfunction Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Female General and cellular metabolism. Vitamins Hemodynamics - drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use inflammation Inflammation - complications Inflammation - drug therapy Inflammation - physiopathology Interleukin-6 - biosynthesis Lipids - blood Male Medical sciences Pharmacodynamics Pharmacology. Drug treatments Salmonella typhi Salmonella Vaccines Simvastatin - pharmacology Simvastatin - therapeutic use statins Vasodilation - drug effects Vasodilation - physiology Young Adult
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