The Sweet Pee Model for Sglt2 Mutation

Inhibiting renal glucose transport is a potential pharmacologic approach to treat diabetes. The renal tubular sodium-glucose transporter 2 (SGLT2) reabsorbs approximately 90% of the filtered glucose load. An animal model with sglt2 dysfunction could provide information regarding the potential long-t...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2011, Vol.22 (1), p.113-123
Hauptverfasser:	LY, Joseph P, ONAY, Tuncer, LEE ADAMSON, S, OSBORNE, Lucy, ROSSANT, Janet, SCHNERMANN, Jurgen, QUAGGIN, Susan E, SISON, Karen, SIVASKANDARAJAH, Gavasker, SABBISETTI, Venkata, LINGLI LI, BONVENTRE, Joseph V, FLENNIKEN, Ann, PARAGAS, Neal, BARASCH, Jon M
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption - physiology Animals Basic Research Biological and medical sciences Blood Pressure - physiology Codon, Nonsense - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose - metabolism Kidney Tubules, Proximal - metabolism Medical sciences Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Mutant Strains Nephrology. Urinary tract diseases Sodium-Glucose Transporter 2 - antagonists & inhibitors Sodium-Glucose Transporter 2 - genetics Sodium-Glucose Transporter 2 - metabolism Streptozocin
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