Comparison of Active Vitamin D Compounds and a Calcimimetic in Mineral Homeostasis

The differential effects between cinacalcet and active vitamin D compounds on parathyroid function, mineral metabolism, and skeletal function are incompletely understood. Here, we studied cinacalcet and active vitamin D compounds in mice expressing the null mutation for Cyp27b1, which encodes 25-hyd...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2010-10, Vol.21 (10), p.1713-1723
Hauptverfasser:	NGUYEN-YAMAMOTO, Loan, BOLIVAR, Isabel, STRUGNELL, Stephen A, GOLTZMAN, David
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - deficiency 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics Animals Basic Research Biological and medical sciences Bone and Bones - drug effects Bone Density - drug effects Bone Density Conservation Agents - pharmacology Bone Density Conservation Agents - therapeutic use Calcification, Physiologic - drug effects Cinacalcet Hydrochloride Homeostasis - drug effects Medical sciences Mice Mutation Naphthalenes - pharmacology Naphthalenes - therapeutic use Nephrology. Urinary tract diseases Osteoblasts - drug effects Osteoclasts - drug effects Parathyroid Glands - drug effects Parathyroid Glands - pathology Vitamin D - pharmacology Vitamin D - therapeutic use Vitamin D Deficiency - blood Vitamin D Deficiency - drug therapy Vitamin D Deficiency - pathology
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