The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine

Animal and human studies suggest that aging is associated with increased formation of kynurenine (KYN) from tryptophan (TRY). The rate-limiting factors of TRY–KYN metabolism are transmembrane transport of TRY, and activity of enzyme, TRY 2,3-dioxygenase (TDO2). Eye-color mutants, white (w1118) (impa...

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Veröffentlicht in:	Journal of Neural Transmission 2010-01, Vol.117 (1), p.23-26
1. Verfasser:	Oxenkrug, Gregory F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Basic Neurosciences Biological Transport, Active - genetics Drosophila melanogaster Eye Female Genetics and Immunology - Short Communication Kynurenine - genetics Kynurenine - metabolism Longevity - genetics Medicine Medicine & Public Health Mutation Neurology Neurosciences Pigmentation - genetics Psychiatry Species Specificity Time Factors Tryptophan - metabolism Tryptophan Oxygenase - genetics
Online-Zugang:	Volltext
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