The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine
Animal and human studies suggest that aging is associated with increased formation of kynurenine (KYN) from tryptophan (TRY). The rate-limiting factors of TRY–KYN metabolism are transmembrane transport of TRY, and activity of enzyme, TRY 2,3-dioxygenase (TDO2). Eye-color mutants, white (w1118) (impa...
Gespeichert in:
| Veröffentlicht in: | Journal of Neural Transmission 2010-01, Vol.117 (1), p.23-26 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 26 |
|---|---|
| container_issue | 1 |
| container_start_page | 23 |
| container_title | Journal of Neural Transmission |
| container_volume | 117 |
| creator | Oxenkrug, Gregory F. |
| description | Animal and human studies suggest that aging is associated with increased formation of kynurenine (KYN) from tryptophan (TRY). The rate-limiting factors of TRY–KYN metabolism are transmembrane transport of TRY, and activity of enzyme, TRY 2,3-dioxygenase (TDO2). Eye-color mutants, white (w1118) (impaired TRY transport) and vermilion (v48a and v2) (deficient TDO activity), were compared with wild-type Oregon-R (Ore-R) strain of
Drosophila melanogaster
. Female 1-day-old adult flies maintained on a standard medium, and acclimatized to 12-h light:12-h dark cycle were collected, and then regularly transferred to fresh medium every 3–4 days. The number of dead flies was recorded at the time of transfer. Forty flies were studied in each experimental group. The life span of w1118 (mean = 45.5 days), and v48a (mean = 47.6 days) and v2 (mean = 43.8 days), were significantly longer than of wild-type Ore-R flies (27.1 days) (
p
|
| doi_str_mv | 10.1007/s00702-009-0341-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3013506</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1915483761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-4c5bb71684b1333364255913cf21282d183476602185632c0c442c01e44df4883</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi0EokvhB3BBFgc-DgGPPxLnUgmVT6kSl3K2vMlk45LYi-207Im_jle7ooAEPowP8_id8cxLyGNgr4Cx5nUqgfGKsbZiQkLV3CErkEJVIGtxl6yYYKxqVS1PyIOUrhhjAI2-T06gbSWAYivy43JEit8z-h57OrkBadpaT8NA38aQwnZ0k6UzTtaHjU0ZI8UdVl2YQqQvbkaXkVrf02uMs5tc8C_pvGTrc6I3Lo_UzVvrYpEeQpxtLsBe-uvOLxG98_iQ3BvslPDR8T4lX96_uzz_WF18_vDp_M1F1cm2zZXs1HrdQK3lGkQ5teRKtSC6gQPXvActZFPXjINWteAd66QsEVDKfpBai1NydtDdLusZ-w59jnYy2-hmG3cmWGf-zHg3mk24NoKBUKwuAs-PAjF8WzBlM7vU4VQGg2FJphFCM97WTSGf_ZcsHTetalQBn_4FXoUl-jKGwjSaa-C8QHCAurKOFHH41TMws3eBObjAFBeYvQvMvoMnv3_29sVx7QXgByCVlN9gvK38b9WfZXu9Zw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217828122</pqid></control><display><type>article</type><title>The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Oxenkrug, Gregory F.</creator><creatorcontrib>Oxenkrug, Gregory F.</creatorcontrib><description>Animal and human studies suggest that aging is associated with increased formation of kynurenine (KYN) from tryptophan (TRY). The rate-limiting factors of TRY–KYN metabolism are transmembrane transport of TRY, and activity of enzyme, TRY 2,3-dioxygenase (TDO2). Eye-color mutants, white (w1118) (impaired TRY transport) and vermilion (v48a and v2) (deficient TDO activity), were compared with wild-type Oregon-R (Ore-R) strain of
Drosophila melanogaster
. Female 1-day-old adult flies maintained on a standard medium, and acclimatized to 12-h light:12-h dark cycle were collected, and then regularly transferred to fresh medium every 3–4 days. The number of dead flies was recorded at the time of transfer. Forty flies were studied in each experimental group. The life span of w1118 (mean = 45.5 days), and v48a (mean = 47.6 days) and v2 (mean = 43.8 days), were significantly longer than of wild-type Ore-R flies (27.1 days) (
p
< 0.001, Logrank test). There were no differences in life span between w1118 and v48a and v2 mutants. Present results suggest that prolongation of life span may be associated with slow rate of KYN formation from TRY.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/s00702-009-0341-7</identifier><identifier>PMID: 19941150</identifier><identifier>CODEN: JNTRF3</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Animals ; Animals, Genetically Modified ; Basic Neurosciences ; Biological Transport, Active - genetics ; Drosophila melanogaster ; Eye ; Female ; Genetics and Immunology - Short Communication ; Kynurenine - genetics ; Kynurenine - metabolism ; Longevity - genetics ; Medicine ; Medicine & Public Health ; Mutation ; Neurology ; Neurosciences ; Pigmentation - genetics ; Psychiatry ; Species Specificity ; Time Factors ; Tryptophan - metabolism ; Tryptophan Oxygenase - genetics</subject><ispartof>Journal of Neural Transmission, 2010-01, Vol.117 (1), p.23-26</ispartof><rights>Springer-Verlag 2009</rights><rights>Springer-Verlag 2010</rights><rights>Springer-Verlag 2009 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-4c5bb71684b1333364255913cf21282d183476602185632c0c442c01e44df4883</citedby><cites>FETCH-LOGICAL-c499t-4c5bb71684b1333364255913cf21282d183476602185632c0c442c01e44df4883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00702-009-0341-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00702-009-0341-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19941150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oxenkrug, Gregory F.</creatorcontrib><title>The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm</addtitle><addtitle>J Neural Transm (Vienna)</addtitle><description>Animal and human studies suggest that aging is associated with increased formation of kynurenine (KYN) from tryptophan (TRY). The rate-limiting factors of TRY–KYN metabolism are transmembrane transport of TRY, and activity of enzyme, TRY 2,3-dioxygenase (TDO2). Eye-color mutants, white (w1118) (impaired TRY transport) and vermilion (v48a and v2) (deficient TDO activity), were compared with wild-type Oregon-R (Ore-R) strain of
Drosophila melanogaster
. Female 1-day-old adult flies maintained on a standard medium, and acclimatized to 12-h light:12-h dark cycle were collected, and then regularly transferred to fresh medium every 3–4 days. The number of dead flies was recorded at the time of transfer. Forty flies were studied in each experimental group. The life span of w1118 (mean = 45.5 days), and v48a (mean = 47.6 days) and v2 (mean = 43.8 days), were significantly longer than of wild-type Ore-R flies (27.1 days) (
p
< 0.001, Logrank test). There were no differences in life span between w1118 and v48a and v2 mutants. Present results suggest that prolongation of life span may be associated with slow rate of KYN formation from TRY.</description><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Basic Neurosciences</subject><subject>Biological Transport, Active - genetics</subject><subject>Drosophila melanogaster</subject><subject>Eye</subject><subject>Female</subject><subject>Genetics and Immunology - Short Communication</subject><subject>Kynurenine - genetics</subject><subject>Kynurenine - metabolism</subject><subject>Longevity - genetics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mutation</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Pigmentation - genetics</subject><subject>Psychiatry</subject><subject>Species Specificity</subject><subject>Time Factors</subject><subject>Tryptophan - metabolism</subject><subject>Tryptophan Oxygenase - genetics</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk1v1DAQhi0EokvhB3BBFgc-DgGPPxLnUgmVT6kSl3K2vMlk45LYi-207Im_jle7ooAEPowP8_id8cxLyGNgr4Cx5nUqgfGKsbZiQkLV3CErkEJVIGtxl6yYYKxqVS1PyIOUrhhjAI2-T06gbSWAYivy43JEit8z-h57OrkBadpaT8NA38aQwnZ0k6UzTtaHjU0ZI8UdVl2YQqQvbkaXkVrf02uMs5tc8C_pvGTrc6I3Lo_UzVvrYpEeQpxtLsBe-uvOLxG98_iQ3BvslPDR8T4lX96_uzz_WF18_vDp_M1F1cm2zZXs1HrdQK3lGkQ5teRKtSC6gQPXvActZFPXjINWteAd66QsEVDKfpBai1NydtDdLusZ-w59jnYy2-hmG3cmWGf-zHg3mk24NoKBUKwuAs-PAjF8WzBlM7vU4VQGg2FJphFCM97WTSGf_ZcsHTetalQBn_4FXoUl-jKGwjSaa-C8QHCAurKOFHH41TMws3eBObjAFBeYvQvMvoMnv3_29sVx7QXgByCVlN9gvK38b9WfZXu9Zw</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Oxenkrug, Gregory F.</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7SS</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100101</creationdate><title>The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine</title><author>Oxenkrug, Gregory F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-4c5bb71684b1333364255913cf21282d183476602185632c0c442c01e44df4883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Basic Neurosciences</topic><topic>Biological Transport, Active - genetics</topic><topic>Drosophila melanogaster</topic><topic>Eye</topic><topic>Female</topic><topic>Genetics and Immunology - Short Communication</topic><topic>Kynurenine - genetics</topic><topic>Kynurenine - metabolism</topic><topic>Longevity - genetics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mutation</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Pigmentation - genetics</topic><topic>Psychiatry</topic><topic>Species Specificity</topic><topic>Time Factors</topic><topic>Tryptophan - metabolism</topic><topic>Tryptophan Oxygenase - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oxenkrug, Gregory F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oxenkrug, Gregory F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine</atitle><jtitle>Journal of Neural Transmission</jtitle><stitle>J Neural Transm</stitle><addtitle>J Neural Transm (Vienna)</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>117</volume><issue>1</issue><spage>23</spage><epage>26</epage><pages>23-26</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTRF3</coden><abstract>Animal and human studies suggest that aging is associated with increased formation of kynurenine (KYN) from tryptophan (TRY). The rate-limiting factors of TRY–KYN metabolism are transmembrane transport of TRY, and activity of enzyme, TRY 2,3-dioxygenase (TDO2). Eye-color mutants, white (w1118) (impaired TRY transport) and vermilion (v48a and v2) (deficient TDO activity), were compared with wild-type Oregon-R (Ore-R) strain of
Drosophila melanogaster
. Female 1-day-old adult flies maintained on a standard medium, and acclimatized to 12-h light:12-h dark cycle were collected, and then regularly transferred to fresh medium every 3–4 days. The number of dead flies was recorded at the time of transfer. Forty flies were studied in each experimental group. The life span of w1118 (mean = 45.5 days), and v48a (mean = 47.6 days) and v2 (mean = 43.8 days), were significantly longer than of wild-type Ore-R flies (27.1 days) (
p
< 0.001, Logrank test). There were no differences in life span between w1118 and v48a and v2 mutants. Present results suggest that prolongation of life span may be associated with slow rate of KYN formation from TRY.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>19941150</pmid><doi>10.1007/s00702-009-0341-7</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9564 |
| ispartof | Journal of Neural Transmission, 2010-01, Vol.117 (1), p.23-26 |
| issn | 0300-9564 1435-1463 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3013506 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Animals, Genetically Modified Basic Neurosciences Biological Transport, Active - genetics Drosophila melanogaster Eye Female Genetics and Immunology - Short Communication Kynurenine - genetics Kynurenine - metabolism Longevity - genetics Medicine Medicine & Public Health Mutation Neurology Neurosciences Pigmentation - genetics Psychiatry Species Specificity Time Factors Tryptophan - metabolism Tryptophan Oxygenase - genetics |
| title | The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T12%3A05%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20extended%20life%20span%20of%20Drosophila%20melanogaster%20eye-color%20(white%20and%20vermilion)%20mutants%20with%20impaired%20formation%20of%20kynurenine&rft.jtitle=Journal%20of%20Neural%20Transmission&rft.au=Oxenkrug,%20Gregory%20F.&rft.date=2010-01-01&rft.volume=117&rft.issue=1&rft.spage=23&rft.epage=26&rft.pages=23-26&rft.issn=0300-9564&rft.eissn=1435-1463&rft.coden=JNTRF3&rft_id=info:doi/10.1007/s00702-009-0341-7&rft_dat=%3Cproquest_pubme%3E1915483761%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217828122&rft_id=info:pmid/19941150&rfr_iscdi=true |