Histidine 103 in Fra2 Is an Iron-Sulfur Cluster Ligand in the [2Fe-2S] Fra2-Grx3 Complex and Is Required for in Vivo Iron Signaling in Yeast

The BolA homologue Fra2 and the cytosolic monothiol glutaredoxins Grx3 and Grx4 together play a key role in regulating iron homeostasis in Saccharomyces cerevisiae. Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response...

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Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (1), p.867-876
Hauptverfasser:	Li, Haoran, Mapolelo, Daphne T., Dingra, Nin N., Keller, Greg, Riggs-Gelasco, Pamela J., Winge, Dennis R., Johnson, Michael K., Outten, Caryn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoproteins - chemistry Apoproteins - genetics Apoproteins - metabolism BolA-like Protein Circular Dichroism (CD) Gene Regulation Histidine Humans Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Iron - metabolism Iron-Sulfur Protein Ligands Mice Molecular Sequence Data Monothiol Glutaredoxin Mutagenesis Mutation Oxidoreductases - chemistry Oxidoreductases - metabolism Protein Metal Ion Interaction Protein Multimerization Protein Stability Protein Structure, Quaternary Raman Spectroscopy Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Signal Transduction Site-directed Mutagenesis Spectrum Analysis Sulfur - metabolism Transcription Factors - metabolism Yeast
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