Protein Kinase D1 Mediates Stimulation of DNA Synthesis and Proliferation in Intestinal Epithelial IEC-18 Cells and in Mouse Intestinal Crypts

We examined whether protein kinase D1 (PKD1), the founding member of a new protein kinase family, plays a critical role in intestinal epithelial cell proliferation. Our results demonstrate that PKD1 activation is sustained, whereas that of PKD2 is transient in intestinal epithelial IEC-18 stimulated...

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Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (1), p.511-520
Hauptverfasser:	Sinnett-Smith, James, Rozengurt, Nora, Kui, Robert, Huang, Carlos, Rozengurt, Enrique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocatalysis Cell Line Cell Proliferation - drug effects Diacylglycerol DNA - biosynthesis DNA Synthesis Enzyme Activation - drug effects Gene Knockdown Techniques IEC-18 Cells Ileum Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - enzymology Intestinal Mucosa - metabolism Intestine Kinetics Mice Mice, Transgenic Neuropeptide Phosphorylation - drug effects Protein Kinase C (PKC) Protein Kinase C - deficiency Protein Kinase C - genetics Protein Kinase C - isolation & purification Protein Kinase C - metabolism Protein Kinases - deficiency Protein Kinases - genetics Protein Kinases - isolation & purification Protein Kinases - metabolism Proto-Oncogene Proteins c-fos - metabolism Rats Receptors, G-Protein-Coupled - agonists Signal Transduction siRNA Transgenic
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