Role of nitric oxide in hepatic ischemia-reperfusion injury
Hepatic ischemia-reperfusion injury (IRI) occurs upon restoration of hepatic blood flow after a period of ischemia. Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IR...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2010-12, Vol.16 (48), p.6079-6086 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Siriussawakul, Arunotai Zaky, Ahmed Lang, John D |
| description | Hepatic ischemia-reperfusion injury (IRI) occurs upon restoration of hepatic blood flow after a period of ischemia. Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress, cytokine release, leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI, role of inhaled NO in ameliorating IRI, modes of delivery, donor drugs and potential side effects of exogenous NO. |
| doi_str_mv | 10.3748/wjg.v16.i48.6079 |
| format | Article |
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Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress, cytokine release, leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI, role of inhaled NO in ameliorating IRI, modes of delivery, donor drugs and potential side effects of exogenous NO.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v16.i48.6079</identifier><identifier>PMID: 21182222</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Humans ; Liver - blood supply ; Liver - cytology ; Liver - metabolism ; Liver - pathology ; Nitric Oxide - metabolism ; Nitric Oxide - therapeutic use ; Nitric Oxide Donors - metabolism ; Reperfusion Injury - drug therapy ; Reperfusion Injury - pathology ; Reperfusion Injury - physiopathology ; Topic Highlight</subject><ispartof>World journal of gastroenterology : WJG, 2010-12, Vol.16 (48), p.6079-6086</ispartof><rights>2010 Baishideng Publishing Group Co., Limited. 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Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress, cytokine release, leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI, role of inhaled NO in ameliorating IRI, modes of delivery, donor drugs and potential side effects of exogenous NO.</description><subject>Humans</subject><subject>Liver - blood supply</subject><subject>Liver - cytology</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide - therapeutic use</subject><subject>Nitric Oxide Donors - metabolism</subject><subject>Reperfusion Injury - drug therapy</subject><subject>Reperfusion Injury - pathology</subject><subject>Reperfusion Injury - physiopathology</subject><subject>Topic Highlight</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkN9LwzAQx4Mobk7ffZK--dSaH22SIggy_AUDQfQ5pEm6ZbTNTNrp_nszNofeyx3343t3HwAuEcwIy_nN13KerRHNbM4zCll5BMYYozLFPIfHYIwgZGlJMBuBsxCWEGJCCnwKRhghjqONwe2ba0zi6qSzvbcqcd9Wm8R2ycKsZB8TNqiFaa1MvVkZXw_Bui7Wl4PfnIOTWjbBXOz9BHw8PrxPn9PZ69PL9H6WqpyiPiVMQ42JZjXVVaVyqVTJVEV1GQNa0JJpyXLNJSqxziU3FVUGY4iKmpGClGQC7na6q6FqjVam671sxMrbVvqNcNKK_5XOLsTcrQWBCBeMRoHrvYB3n4MJvWjjW6ZpZGfcEATHKK5DvIidcNepvAvBm_qwBUGxRS4ichGRi4hcbJHHkau_1x0GfhmTH8IAf6c</recordid><startdate>20101228</startdate><enddate>20101228</enddate><creator>Siriussawakul, Arunotai</creator><creator>Zaky, Ahmed</creator><creator>Lang, John D</creator><general>Baishideng Publishing Group Co., Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101228</creationdate><title>Role of nitric oxide in hepatic ischemia-reperfusion injury</title><author>Siriussawakul, Arunotai ; Zaky, Ahmed ; Lang, John D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-37d0d23d7f6dbbc4acc97cb6d9cc965697da74d8a192d4a8eb6ce22015f735393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Humans</topic><topic>Liver - blood supply</topic><topic>Liver - cytology</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide - therapeutic use</topic><topic>Nitric Oxide Donors - metabolism</topic><topic>Reperfusion Injury - drug therapy</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - physiopathology</topic><topic>Topic Highlight</topic><toplevel>online_resources</toplevel><creatorcontrib>Siriussawakul, Arunotai</creatorcontrib><creatorcontrib>Zaky, Ahmed</creatorcontrib><creatorcontrib>Lang, John D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siriussawakul, Arunotai</au><au>Zaky, Ahmed</au><au>Lang, John D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of nitric oxide in hepatic ischemia-reperfusion injury</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2010-12-28</date><risdate>2010</risdate><volume>16</volume><issue>48</issue><spage>6079</spage><epage>6086</epage><pages>6079-6086</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>Hepatic ischemia-reperfusion injury (IRI) occurs upon restoration of hepatic blood flow after a period of ischemia. Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress, cytokine release, leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI, role of inhaled NO in ameliorating IRI, modes of delivery, donor drugs and potential side effects of exogenous NO.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>21182222</pmid><doi>10.3748/wjg.v16.i48.6079</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2010-12, Vol.16 (48), p.6079-6086 |
| issn | 1007-9327 2219-2840 |
| language | eng |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Humans Liver - blood supply Liver - cytology Liver - metabolism Liver - pathology Nitric Oxide - metabolism Nitric Oxide - therapeutic use Nitric Oxide Donors - metabolism Reperfusion Injury - drug therapy Reperfusion Injury - pathology Reperfusion Injury - physiopathology Topic Highlight |
| title | Role of nitric oxide in hepatic ischemia-reperfusion injury |
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