Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo

Hypothalamic nutrient sensing regulates glucose production, but the neuronal circuits involved remain largely unknown. Recent studies underscore the importance of N-methyl-d-aspartate (NMDA) receptors in the dorsal vagal complex in glucose regulation. These studies raise the possibility that hypotha...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2011-01, Vol.60 (1), p.107-113
Hauptverfasser:	LAM, Carol K. L, CHARI, Madhu, RUTTER, Guy A, LAM, Tony K. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Adenoviruses Animals Biological and medical sciences Catheterization Catheterization, Central Venous Catheters Chemoreception Circuits Company business management Diabetes Diabetes mellitus Diabetes. Impaired glucose tolerance Dizocilpine Maleate - pharmacology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Forebrain Gluconeogenesis - drug effects Gluconeogenesis - physiology Glucose Glucose - biosynthesis Glucose - metabolism Glucose Clamp Technique - methods Glutamic acid receptors Glutamic acid receptors (ionotropic) Hindbrain Homeostasis Homeostasis - drug effects Hypothalamus Hypothalamus - physiology Insulin Intravenous administration Kinases Kinetics Lactates - metabolism Lactic acid Male Management Medical sciences Metabolism MK-801 N-Methyl-D-aspartic acid receptors N-Methylaspartate - physiology Neurons - physiology Nutrients Pancreas Prosencephalon - physiology Proteins Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology Research design Rhombencephalon - physiology Sampling Vagus nerve Vagus Nerve - physiology
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