Controlled Delivery of Transforming Growth Factor β1 by Self-Assembling Peptide Hydrogels Induces Chondrogenesis of Bone Marrow Stromal Cells and Modulates Smad2/3 Signaling

Self-assembling peptide hydrogels were modified to deliver transforming growth factor β1 (TGF-β1) to encapsulated bone-marrow-derived stromal cells (BMSCs) for cartilage tissue engineering applications using two different approaches: (i) biotin-streptavidin tethering; (ii) adsorption to the peptide...

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Veröffentlicht in:	Tissue engineering. Part A 2011-01, Vol.17 (1-2), p.83-92
Hauptverfasser:	Kopesky, Paul W., Vanderploeg, Eric J., Kisiday, John D., Frisbie, David D., Sandy, John D., Grodzinsky, Alan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cartilage cells Cattle Cells, Cultured Chondrogenesis - drug effects Growth Horses Hydrogels - chemistry Methods Original Original Articles Peptides - chemistry Physiological aspects Smad2 Protein - metabolism Smad3 Protein - metabolism Tissue Engineering Transforming Growth Factor beta1 - chemistry Transforming Growth Factor beta1 - pharmacology Transforming growth factors
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