Antibody-Unfolding and Metastable-State Binding in Force Spectroscopy and Recognition Imaging

Force spectroscopy and recognition imaging are important techniques for characterizing and mapping molecular interactions. In both cases, an antibody is pulled away from its target in times that are much less than the normal residence time of the antibody on its target. The distribution of pulling l...

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Veröffentlicht in:	Biophysical journal 2011-01, Vol.100 (1), p.243-250
Hauptverfasser:	Kaur, Parminder, Qiang-Fu, Fuhrmann, Alexander, Ros, Robert, Kutner, Linda Obenauer, Schneeweis, Lumelle A., Navoa, Ryman, Steger, Kirby, Xie, Lei, Yonan, Christopher, Abraham, Ralph, Grace, Michael J., Lindsay, Stuart
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies atomic force microscopy Binding Binding sites Biophysics chromosome mapping Humans image analysis Imaging Imaging, Three-Dimensional - methods Immunoglobulin G - chemistry Immunoglobulin G - metabolism Kinetics Loading rate Metastable state Protein Binding Protein Conformation Protein Unfolding Recognition Spectroscopy Spectroscopy, Imaging, and Other Techniques Spectrum analysis Spectrum Analysis - methods Thermodynamics
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