Effects of dantrolene on apoptosis and immunohistochemical expression of NeuN in the spinal cord after traumatic injury in rats

Summary Dantrolene has been shown to be neuroprotective by reducing neuronal apoptosis after brain injury in several animal models of neurological disorders. In this study, we investigated the effects of dantrolene on experimental spinal cord injury (SCI). Forty‐six male Wistar rats were laminectomi...

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Veröffentlicht in:	International journal of experimental pathology 2010-12, Vol.91 (6), p.530-536
Hauptverfasser:	Torres, Bruno Benetti Junta, Caldeira, Fátima Maria Caetano, Gomes, Mardelene Geísa, Serakides, Rogéria, De Marco Viott, Aline, Bertagnolli, Angélica Cavalheiro, Fukushima, Fabíola Bono, De Oliveira, Karen Maciel, Gomes, Marcus Vinícius, De Melo, Eliane Gonçalves
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antigens, Nuclear - metabolism apoptosis Apoptosis - drug effects Caspase 3 - metabolism caspase-3 Cell Count dantrolene Dantrolene - pharmacology Dantrolene - therapeutic use immunochemistry Immunohistochemistry In Situ Nick-End Labeling Laminectomy Male Nerve Tissue Proteins - metabolism NeuN Neurons - drug effects Neurons - metabolism Neurons - pathology Original Random Allocation Rats Rats, Wistar Recovery of Function Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology spinal cord injury TUNEL-staining
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