Selective knockdown of NMDA receptors in primary afferent neurons decreases pain during phase 2 of the formalin test

Abstract The role of NMDA receptors (NMDARs) expressed by primary afferent neurons in nociception remains controversial. The aim of this study was to develop mice with a tissue selective knockdown of NMDARs in these neurons and to evaluate their behavioral responses to different types of painful sti...

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Veröffentlicht in:	Neuroscience 2011-01, Vol.172 (1), p.474-482
Hauptverfasser:	McRoberts, J.A, Ennes, H.S, Marvizón, J.C.G, Fanselow, M.S, Mayer, E.A, Vissel, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - cytology Afferent Pathways - metabolism Afferent Pathways - physiopathology Animals Biological and medical sciences Cells, Cultured Disease Models, Animal dorsal root ganglia Down-Regulation - genetics Female Fundamental and applied biological sciences. Psychology Ganglia, Spinal - cytology Ganglia, Spinal - metabolism hyperalgesia Male Medical sciences Mice Mice, Transgenic Nervous system (semeiology, syndromes) Nervous system as a whole Neurology NMDA receptor nociception Nociceptors - cytology Nociceptors - metabolism Pain - genetics Pain - metabolism Pain - physiopathology Pain Measurement - methods presynaptic Receptors, N-Methyl-D-Aspartate - deficiency Receptors, N-Methyl-D-Aspartate - genetics Sensory Receptor Cells - cytology Sensory Receptor Cells - metabolism Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs
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