Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity

Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteoblast maturation, thereby causing bone loss in Runx2 transgenic mice. Zinc finger protein 521 (Zfp521) antagonizes Runx2 in vivo. Eliminating one Zfp521 allele mitigates the cleidocranial dysplasi...

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Veröffentlicht in:	The Journal of cell biology 2010-12, Vol.191 (7), p.1271-1283
Hauptverfasser:	Hesse, Eric, Saito, Hiroaki, Kiviranta, Riku, Correa, Diego, Yamana, Kei, Neff, Lynn, Toben, Daniel, Duda, Georg, Atfi, Azeddine, Geoffroy, Valérie, Horne, William C, Baron, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Animals, Newborn Antibodies Bone and Bones - abnormalities Bone and Bones - embryology Bone and Bones - metabolism Bone and Bones - pathology Bone Development - physiology Bone Diseases, Metabolic - genetics Bone Diseases, Metabolic - metabolism Bone marrow cells Bone Remodeling - physiology Bones Calcification, Physiologic - genetics Cell Count Cell Differentiation - genetics Cell division Core Binding Factor Alpha 1 Subunit - antagonists & inhibitors Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Extracellular Matrix Proteins - genetics Fractures, Spontaneous - genetics Gene Expression - genetics Heterozygote Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - metabolism Maturation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mice Mice, Inbred Strains Mice, Transgenic Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteocalcin - genetics Osteogenesis - physiology Osteomyelitis Osteopontin - genetics Osteoprotegerin - genetics Phenotypes Protein Binding - physiology Protein Interaction Domains and Motifs - physiology Proteins RANK Ligand - genetics Rats Repression Response Elements - physiology Rodents Sp7 Transcription Factor Transcription Factors - genetics Transcription, Genetic - drug effects Transcription, Genetic - genetics Transgenic animals Zinc Zinc Fingers - physiology
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