Frataxin Depletion in Yeast Triggers Up-regulation of Iron Transport Systems before Affecting Iron-Sulfur Enzyme Activities

The primary function of frataxin, a mitochondrial protein involved in iron homeostasis, remains controversial. Using a yeast model of conditional expression of the frataxin homologue YFH1, we analyzed the primary effects of YFH1 depletion. The main conclusion unambiguously points to the up-regulatio...

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Veröffentlicht in:	The Journal of biological chemistry 2010-12, Vol.285 (53), p.41653-41664
Hauptverfasser:	Moreno-Cermeño, Armando, Obis, Èlia, Bellí, Gemma, Cabiscol, Elisa, Ros, Joaquim, Tamarit, Jordi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitate Hydratase - metabolism Cation Transport Proteins - metabolism Frataxin Friedreich Ataxia Gene Expression Regulation, Fungal Ions Iron - metabolism Iron-Binding Proteins - genetics Iron-Binding Proteins - physiology Iron-Sulfur Protein Iron-Sulfur Proteins - chemistry Manganese Manganese - chemistry Manganese - metabolism Metabolism Models, Biological Oxidative Stress Oxygen Consumption Plasmids - metabolism Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Subcellular Fractions - metabolism Up-Regulation Yeast
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