Lethal host-versus-graft disease and hypereosinophilia in the absence of MHC I-T-cell interactions

Neonatal injection of semiallogeneic spleen cells in BALB/c mice induces a self-limited state of chimerism that promotes the differentiation of donor-specific CD4 T cells toward the Th2 phenotype. Here we show that injection of spleen cells from beta2-microglobulin-deficient (BALB/c x C57BL/6) F1 mi...

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Veröffentlicht in:	The Journal of clinical investigation 2000-04, Vol.105 (8), p.1125-1132
Hauptverfasser:	Coudert, J D, Foucras, G, Demur, C, Coureau, C, Mazerolles, C, Delsol, G, Druet, P, Guéry, J C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta 2-Microglobulin - genetics beta 2-Microglobulin - immunology Female Histocompatibility Antigens Class I - immunology Host vs Graft Reaction - immunology Hypereosinophilic Syndrome - immunology Lymphoid Tissue - immunology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Th2 Cells - immunology
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