High Antimetastatic Efficacy of MEN4901/T-0128, a Novel Camptothecin Carboxymethyldextran Conjugate

The antimetastatic activity of a novel camptothecan conjugate, MEN4901/T-0128, in which 7-ethyl-10-aminopropyloxy-camptothecin (T-2513) is bound to a biodegradable carboxymethyldextran via a Gly-Gly-Gly linker, was observed in this study. High antimetastatic activity of MEN4901/T-0128 was demonstrat...

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Veröffentlicht in:	The Journal of surgical research 2011-12, Vol.171 (2), p.684-690
Hauptverfasser:	Ma, Huaiyu, M.D, Li, Xiaoming, M.D., Ph.D, Yang, Zhijian, M.D, Okuno, Satoshi, Ph.D, Kawaguchi, Takayuki, Ph.D, Yagi, Shigeo, Ph.D, Bouvet, Michael, M.D, Hoffman, Robert M., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - secondary Animals Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Body Weight - drug effects camptothecin Camptothecin - analogs & derivatives Camptothecin - pharmacology Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Dextrans - pharmacokinetics Dextrans - pharmacology Dose-Response Relationship, Drug efficacy General aspects Green Fluorescent Proteins - genetics HT29 Cells Humans Irinotecan Medical sciences metastasis Mice Mice, Nude nude mice orthotopic model polymer conjugate Prodrugs - pharmacology Surgery Topotecan - analogs & derivatives Topotecan - pharmacology Xenograft Model Antitumor Assays
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