Neuronal gap junctions are required for NMDA receptor-mediated excitotoxicity: implications in ischemic stroke

N-methyl-D-aspartate receptors (NMDARs) play an important role in cell survival versus cell death decisions during neuronal development, ischemia, trauma, and epilepsy. Coupling of neurons by electrical synapses (gap junctions) is high or increases in neuronal networks during all these conditions. I...

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Veröffentlicht in:	Journal of neurophysiology 2010-12, Vol.104 (6), p.3551-3556
Hauptverfasser:	Wang, Yongfu, Denisova, Janna V, Kang, Ki Sung, Fontes, Joseph D, Zhu, Bao Ting, Belousov, Andrei B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Blood-Brain Barrier Brain Ischemia - chemically induced Brain Ischemia - physiopathology Cells, Cultured - drug effects Cells, Cultured - physiology Connexins - deficiency Dentate Gyrus - drug effects Dentate Gyrus - pathology Dizocilpine Maleate - pharmacology Dizocilpine Maleate - therapeutic use Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Gap Junction delta-2 Protein Gap Junctions - drug effects Gap Junctions - physiology Male Mefloquine - pharmacology Mefloquine - therapeutic use Mice Mice, Inbred C57BL Mice, Knockout N-Methylaspartate - pharmacokinetics N-Methylaspartate - toxicity Nerve Degeneration - chemically induced Nerve Degeneration - prevention & control Neurons - physiology Neurotoxins - pharmacokinetics Neurotoxins - toxicity Patch-Clamp Techniques Photochemistry Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - physiology Rose Bengal - radiation effects Rose Bengal - toxicity
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