Reactivation of epigenetically silenced HER4/ERBB4 results in apoptosis of breast tumor cells

Experimental and clinical data support a growth inhibitory role for HER4 in breast cancer. Clinically HER4 expression is extinguished during breast tumorigenesis supporting a tumor suppressor function for HER4, however, a molecular mechanism to explain the selective loss of HER4 expression has remai...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2010-09, Vol.29 (37), p.5214-5219
Hauptverfasser:	Das, P M, Thor, A D, Edgerton, S M, Barry, S K, Chen, D F, Jones, F E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/176/1988 631/67/581 631/80/82/23 692/699/67/1347 Ageing, cell death Analysis Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Care and treatment Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Development and progression DNA Epigenesis, Genetic Epigenetics Female Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Gynecology. Andrology. Obstetrics Human Genetics Humans Immunohistochemistry Internal Medicine Mammary gland diseases Medical sciences Medicine Medicine & Public Health Metastasis Methylation Molecular and cellular biology Oncology Promoter Regions, Genetic Proteins Receptor, Epidermal Growth Factor - genetics Receptor, ErbB-4 Short Communication Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!