Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells

Keratinocyte growth factor (KGF) has efficacy in several experimental models of lung injury; however, the mechanisms underlying KGF's protective effect remain incompletely understood. This study was undertaken to determine whether KGF augments barrier function in primary rat alveolar epithelial...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2010-12, Vol.299 (6), p.L724-L734
Hauptverfasser:	LaFemina, Michael J, Rokkam, Deepti, Chandrasena, Anita, Pan, Jue, Bajaj, Anisha, Johnson, Meshell, Frank, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Air Barrier - drug effects Cell growth Cells Cells, Cultured Claudins - genetics Claudins - metabolism Cytoskeleton - drug effects Cytoskeleton - metabolism Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Fibroblast Growth Factor 7 - genetics Fibroblast Growth Factor 7 - metabolism Fibroblast Growth Factor 7 - pharmacology Humans Lungs Male Membrane Proteins - genetics Membrane Proteins - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Pulmonary Alveoli - cytology Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Rats Rats, Sprague-Dawley Respiratory Mucosa - cytology Ribonucleic acid RNA Rodents Tight Junctions - metabolism
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