A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

The pro-oncogenic transcription factor STAT3 is constitutively activated in a wide variety of tumours that often become addicted to its activity, but no unifying view of a core function determining this widespread STAT3-dependence has yet emerged. We show here that constitutively active STAT3 acts a...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2010-11, Vol.2 (11), p.823-842
Hauptverfasser:	Demaria, Marco, Giorgi, Carlotta, Lebiedzinska, Magdalena, Esposito, Giovanna, D'Angeli, Luca, Bartoli, Antonietta, Gough, Daniel J, Turkson, James, Levy, David E, Watson, Christine J, Wieckowski, Mariusz R, Provero, Paolo, Pinton, Paolo, Poli, Valeria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Transformation, Neoplastic Cells, Cultured Energy Metabolism Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - physiology Gene Expression Profiling Glycolysis - physiology Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Mice, Transgenic Microarray Analysis Mitochondria - metabolism Neoplasms - genetics Neoplasms - metabolism Reactive Oxygen Species - metabolism Research Paper Signal Transduction - physiology STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism
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