Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis

E-cadherin is the primary cell adhesion molecule within the epithelium, and loss of this protein is associated with a more aggressive tumour phenotype and poorer patient prognosis in many cancers. Loss of E-cadherin is a defining characteristic of epithelial-mesenchymal transition (EMT), a process a...

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Veröffentlicht in:	Journal of Oncology 2011, Vol.2011 (2011), p.634-652
Hauptverfasser:	Mohamet, Lisa, Hawkins, Kate, Ward, Christopher M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Review
Online-Zugang:	Volltext
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