A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space

We present here a comprehensive analysis of proteases in the peptide substrate space and demonstrate its applicability for lead discovery. Aligned octapeptide substrates of 498 proteases taken from the MEROPS peptidase database were used for the in silico analysis. A multiple‐category naïve Bayes mo...

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Veröffentlicht in:	Protein science 2010-11, Vol.19 (11), p.2096-2109
Hauptverfasser:	Sukuru, Sai Chetan K., Nigsch, Florian, Quancard, Jean, Renatus, Martin, Chopra, Rajiv, Brooijmans, Natasja, Mikhailov, Dmitri, Deng, Zhan, Cornett, Allen, Jenkins, Jeremy L., Hommel, Ulrich, Davies, John W., Glick, Meir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - chemistry Bacterial Proteins - metabolism Bayes Theorem chemical space Computational Biology - methods Computer Simulation Humans in silico lead discovery Oligopeptides - chemistry Peptide Hydrolases - chemistry Peptide Hydrolases - metabolism proteases Protein Structure, Tertiary Rats Reproducibility of Results substrate space Viral Proteins - chemistry Viral Proteins - metabolism
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