Developmental regulation of axon branching in the vertebrate nervous system
During nervous system development, axons generate branches to connect with multiple synaptic targets. As with axon growth and guidance, axon branching is tightly controlled in order to establish functional neural circuits, yet the mechanisms that regulate this important process are less well underst...
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| Veröffentlicht in: | Development (Cambridge) 2011-01, Vol.138 (2), p.183-195 |
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| container_title | Development (Cambridge) |
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| creator | Gibson, Daniel A Ma, Le |
| description | During nervous system development, axons generate branches to connect with multiple synaptic targets. As with axon growth and guidance, axon branching is tightly controlled in order to establish functional neural circuits, yet the mechanisms that regulate this important process are less well understood. Here, we review recent advances in the study of several common branching processes in the vertebrate nervous system. By focusing on each step in these processes we illustrate how different types of branching are regulated by extracellular cues and neural activity, and highlight some common principles that underlie the establishment of complex neural circuits in vertebrate development. |
| doi_str_mv | 10.1242/dev.046441 |
| format | Article |
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| ispartof | Development (Cambridge), 2011-01, Vol.138 (2), p.183-195 |
| issn | 0950-1991 1477-9129 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Axons - physiology Axons - ultrastructure Models, Neurological Nervous System - growth & development Nervous System Physiological Phenomena Neurogenesis - physiology Neurons - physiology Neurons - ultrastructure Review Signal Transduction Synapses - physiology Vertebrates - growth & development Vertebrates - physiology |
| title | Developmental regulation of axon branching in the vertebrate nervous system |
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