Metformin and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients
OBJECTIVE: Metformin is associated with reduced cancer-related morbidity and mortality. The aim of this study was to assess the effect of metformin on cancer incidence in a consecutive series of insulin-treated patients. RESEARCH DESIGN AND METHODS: A nested case-control study was performed in a coh...
Gespeichert in:
| Veröffentlicht in: | Diabetes care 2011-01, Vol.34 (1), p.129-131 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 131 |
|---|---|
| container_issue | 1 |
| container_start_page | 129 |
| container_title | Diabetes care |
| container_volume | 34 |
| creator | Monami, Matteo Colombi, Claudia Balzi, Daniela Dicembrini, Ilaria Giannini, Stefano Melani, Cecilia Vitale, Valentina Romano, Desiderio Barchielli, Alessandro Marchionni, Niccolò Rotella, Carlo Maria Mannucci, Edoardo |
| description | OBJECTIVE: Metformin is associated with reduced cancer-related morbidity and mortality. The aim of this study was to assess the effect of metformin on cancer incidence in a consecutive series of insulin-treated patients. RESEARCH DESIGN AND METHODS: A nested case-control study was performed in a cohort of 1,340 patients by sampling, for each case subject, age-, sex-, and BMI-matched control subjects from the same cohort. RESULTS: During a median follow-up of 75.9 months, 112 case patients who developed incident cancer and were compared with 370 control subjects. A significantly lower proportion of case subjects were exposed to metformin and sulfonylureas. After adjustment for comorbidity, glargine, and total insulin doses, exposure to metformin, but not to sulfonylureas, was associated with reduced incidence of cancer (odds ratio 0.46 [95% CI 0.25-0.85], P = 0.014 and 0.75 [0.39-1.45], P = 0.40, respectively). CONCLUSIONS: The reduction of cancer risk could be a further relevant reason for maintaining use of metformin in insulin-treated patients. |
| doi_str_mv | 10.2337/dc10-1287 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3005459</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A246253701</galeid><sourcerecordid>A246253701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c626t-ca266728b5716d22a72bda1a647fc56a33c07304053c064b45b4d0fda2a6802b3</originalsourceid><addsrcrecordid>eNptkk1v1DAQhi0EotvCgT8AEQghDin-jnNBqpaviqIisT1bE8dZXGWdxU4q9d8z0S6FopUPHnmeeWc8egl5xugpF6J61zpGS8ZN9YAsWC1UqZQ0D8mCMlmXqq75ETnO-ZpSKqUxj8kRp7WhkqkF-frNj92QNiEWENtiCdH5VFw6N6XkMS4wcR7z1IdYrpKH0bfF6nbrC158CND4MbjiO4zBxzE_IY866LN_ur9PyNWnj6vll_Li8vP58uyidJrrsXTAta64aVTFdMs5VLxpgYGWVeeUBiEcrQSVVGGgZSNVI1vatcBBG8obcULe73S3U7PxrcPeCXq7TWED6dYOEOz9TAw_7Xq4sYJSJVWNAm_2Amn4Nfk82k3Izvc9RD9M2RrOhcZ1SiRf_kdeD1OK-DtrhKKV0jVH6NUOWkPvbYjdgF3dLGnPuNRciYoypMoD1NpHjyMO0XcBn-_xpwd4PK3fBHew4O2uwKUh5-S7u40wamef2NkndvYJss__XeEd-ccYCLzeA5Ad9F1CY4T8lxOGVVLN3Isd18FgYZ2QufrBcRqKRsSeWvwGIXPKsg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>835075692</pqid></control><display><type>article</type><title>Metformin and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Monami, Matteo ; Colombi, Claudia ; Balzi, Daniela ; Dicembrini, Ilaria ; Giannini, Stefano ; Melani, Cecilia ; Vitale, Valentina ; Romano, Desiderio ; Barchielli, Alessandro ; Marchionni, Niccolò ; Rotella, Carlo Maria ; Mannucci, Edoardo</creator><creatorcontrib>Monami, Matteo ; Colombi, Claudia ; Balzi, Daniela ; Dicembrini, Ilaria ; Giannini, Stefano ; Melani, Cecilia ; Vitale, Valentina ; Romano, Desiderio ; Barchielli, Alessandro ; Marchionni, Niccolò ; Rotella, Carlo Maria ; Mannucci, Edoardo</creatorcontrib><description>OBJECTIVE: Metformin is associated with reduced cancer-related morbidity and mortality. The aim of this study was to assess the effect of metformin on cancer incidence in a consecutive series of insulin-treated patients. RESEARCH DESIGN AND METHODS: A nested case-control study was performed in a cohort of 1,340 patients by sampling, for each case subject, age-, sex-, and BMI-matched control subjects from the same cohort. RESULTS: During a median follow-up of 75.9 months, 112 case patients who developed incident cancer and were compared with 370 control subjects. A significantly lower proportion of case subjects were exposed to metformin and sulfonylureas. After adjustment for comorbidity, glargine, and total insulin doses, exposure to metformin, but not to sulfonylureas, was associated with reduced incidence of cancer (odds ratio 0.46 [95% CI 0.25-0.85], P = 0.014 and 0.75 [0.39-1.45], P = 0.40, respectively). CONCLUSIONS: The reduction of cancer risk could be a further relevant reason for maintaining use of metformin in insulin-treated patients.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc10-1287</identifier><identifier>PMID: 20980415</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Aged ; Biological and medical sciences ; Cancer ; Cancer patients ; Cancer therapies ; Care and treatment ; Case-Control Studies ; Design ; Diabetes ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes. Impaired glucose tolerance ; Diabetics ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fees & charges ; Female ; Health aspects ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulin - analogs & derivatives ; Insulin - therapeutic use ; Insulin Glargine ; Insulin, Long-Acting ; Kinases ; Male ; Medical sciences ; Metabolic diseases ; Metformin ; Metformin - therapeutic use ; Middle Aged ; Miscellaneous ; Mortality ; Multivariate analysis ; Neoplasms - epidemiology ; Neoplasms - prevention & control ; Oncology, Experimental ; Original Research ; Pharmaceutical industry ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Sulfonylurea Compounds - therapeutic use ; Teaching hospitals</subject><ispartof>Diabetes care, 2011-01, Vol.34 (1), p.129-131</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 American Diabetes Association</rights><rights>Copyright American Diabetes Association Jan 2011</rights><rights>2011 by the American Diabetes Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c626t-ca266728b5716d22a72bda1a647fc56a33c07304053c064b45b4d0fda2a6802b3</citedby><cites>FETCH-LOGICAL-c626t-ca266728b5716d22a72bda1a647fc56a33c07304053c064b45b4d0fda2a6802b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23817455$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20980415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monami, Matteo</creatorcontrib><creatorcontrib>Colombi, Claudia</creatorcontrib><creatorcontrib>Balzi, Daniela</creatorcontrib><creatorcontrib>Dicembrini, Ilaria</creatorcontrib><creatorcontrib>Giannini, Stefano</creatorcontrib><creatorcontrib>Melani, Cecilia</creatorcontrib><creatorcontrib>Vitale, Valentina</creatorcontrib><creatorcontrib>Romano, Desiderio</creatorcontrib><creatorcontrib>Barchielli, Alessandro</creatorcontrib><creatorcontrib>Marchionni, Niccolò</creatorcontrib><creatorcontrib>Rotella, Carlo Maria</creatorcontrib><creatorcontrib>Mannucci, Edoardo</creatorcontrib><title>Metformin and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE: Metformin is associated with reduced cancer-related morbidity and mortality. The aim of this study was to assess the effect of metformin on cancer incidence in a consecutive series of insulin-treated patients. RESEARCH DESIGN AND METHODS: A nested case-control study was performed in a cohort of 1,340 patients by sampling, for each case subject, age-, sex-, and BMI-matched control subjects from the same cohort. RESULTS: During a median follow-up of 75.9 months, 112 case patients who developed incident cancer and were compared with 370 control subjects. A significantly lower proportion of case subjects were exposed to metformin and sulfonylureas. After adjustment for comorbidity, glargine, and total insulin doses, exposure to metformin, but not to sulfonylureas, was associated with reduced incidence of cancer (odds ratio 0.46 [95% CI 0.25-0.85], P = 0.014 and 0.75 [0.39-1.45], P = 0.40, respectively). CONCLUSIONS: The reduction of cancer risk could be a further relevant reason for maintaining use of metformin in insulin-treated patients.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Design</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetics</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fees & charges</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - analogs & derivatives</subject><subject>Insulin - therapeutic use</subject><subject>Insulin Glargine</subject><subject>Insulin, Long-Acting</subject><subject>Kinases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metformin</subject><subject>Metformin - therapeutic use</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - prevention & control</subject><subject>Oncology, Experimental</subject><subject>Original Research</subject><subject>Pharmaceutical industry</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Sulfonylurea Compounds - therapeutic use</subject><subject>Teaching hospitals</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1v1DAQhi0EotvCgT8AEQghDin-jnNBqpaviqIisT1bE8dZXGWdxU4q9d8z0S6FopUPHnmeeWc8egl5xugpF6J61zpGS8ZN9YAsWC1UqZQ0D8mCMlmXqq75ETnO-ZpSKqUxj8kRp7WhkqkF-frNj92QNiEWENtiCdH5VFw6N6XkMS4wcR7z1IdYrpKH0bfF6nbrC158CND4MbjiO4zBxzE_IY866LN_ur9PyNWnj6vll_Li8vP58uyidJrrsXTAta64aVTFdMs5VLxpgYGWVeeUBiEcrQSVVGGgZSNVI1vatcBBG8obcULe73S3U7PxrcPeCXq7TWED6dYOEOz9TAw_7Xq4sYJSJVWNAm_2Amn4Nfk82k3Izvc9RD9M2RrOhcZ1SiRf_kdeD1OK-DtrhKKV0jVH6NUOWkPvbYjdgF3dLGnPuNRciYoypMoD1NpHjyMO0XcBn-_xpwd4PK3fBHew4O2uwKUh5-S7u40wamef2NkndvYJss__XeEd-ccYCLzeA5Ad9F1CY4T8lxOGVVLN3Isd18FgYZ2QufrBcRqKRsSeWvwGIXPKsg</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Monami, Matteo</creator><creator>Colombi, Claudia</creator><creator>Balzi, Daniela</creator><creator>Dicembrini, Ilaria</creator><creator>Giannini, Stefano</creator><creator>Melani, Cecilia</creator><creator>Vitale, Valentina</creator><creator>Romano, Desiderio</creator><creator>Barchielli, Alessandro</creator><creator>Marchionni, Niccolò</creator><creator>Rotella, Carlo Maria</creator><creator>Mannucci, Edoardo</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Metformin and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients</title><author>Monami, Matteo ; Colombi, Claudia ; Balzi, Daniela ; Dicembrini, Ilaria ; Giannini, Stefano ; Melani, Cecilia ; Vitale, Valentina ; Romano, Desiderio ; Barchielli, Alessandro ; Marchionni, Niccolò ; Rotella, Carlo Maria ; Mannucci, Edoardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c626t-ca266728b5716d22a72bda1a647fc56a33c07304053c064b45b4d0fda2a6802b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Design</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetics</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fees & charges</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - analogs & derivatives</topic><topic>Insulin - therapeutic use</topic><topic>Insulin Glargine</topic><topic>Insulin, Long-Acting</topic><topic>Kinases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metformin</topic><topic>Metformin - therapeutic use</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - prevention & control</topic><topic>Oncology, Experimental</topic><topic>Original Research</topic><topic>Pharmaceutical industry</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Sulfonylurea Compounds - therapeutic use</topic><topic>Teaching hospitals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monami, Matteo</creatorcontrib><creatorcontrib>Colombi, Claudia</creatorcontrib><creatorcontrib>Balzi, Daniela</creatorcontrib><creatorcontrib>Dicembrini, Ilaria</creatorcontrib><creatorcontrib>Giannini, Stefano</creatorcontrib><creatorcontrib>Melani, Cecilia</creatorcontrib><creatorcontrib>Vitale, Valentina</creatorcontrib><creatorcontrib>Romano, Desiderio</creatorcontrib><creatorcontrib>Barchielli, Alessandro</creatorcontrib><creatorcontrib>Marchionni, Niccolò</creatorcontrib><creatorcontrib>Rotella, Carlo Maria</creatorcontrib><creatorcontrib>Mannucci, Edoardo</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monami, Matteo</au><au>Colombi, Claudia</au><au>Balzi, Daniela</au><au>Dicembrini, Ilaria</au><au>Giannini, Stefano</au><au>Melani, Cecilia</au><au>Vitale, Valentina</au><au>Romano, Desiderio</au><au>Barchielli, Alessandro</au><au>Marchionni, Niccolò</au><au>Rotella, Carlo Maria</au><au>Mannucci, Edoardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metformin and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>34</volume><issue>1</issue><spage>129</spage><epage>131</epage><pages>129-131</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE: Metformin is associated with reduced cancer-related morbidity and mortality. The aim of this study was to assess the effect of metformin on cancer incidence in a consecutive series of insulin-treated patients. RESEARCH DESIGN AND METHODS: A nested case-control study was performed in a cohort of 1,340 patients by sampling, for each case subject, age-, sex-, and BMI-matched control subjects from the same cohort. RESULTS: During a median follow-up of 75.9 months, 112 case patients who developed incident cancer and were compared with 370 control subjects. A significantly lower proportion of case subjects were exposed to metformin and sulfonylureas. After adjustment for comorbidity, glargine, and total insulin doses, exposure to metformin, but not to sulfonylureas, was associated with reduced incidence of cancer (odds ratio 0.46 [95% CI 0.25-0.85], P = 0.014 and 0.75 [0.39-1.45], P = 0.40, respectively). CONCLUSIONS: The reduction of cancer risk could be a further relevant reason for maintaining use of metformin in insulin-treated patients.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>20980415</pmid><doi>10.2337/dc10-1287</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-5992 |
| ispartof | Diabetes care, 2011-01, Vol.34 (1), p.129-131 |
| issn | 0149-5992 1935-5548 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3005459 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Biological and medical sciences Cancer Cancer patients Cancer therapies Care and treatment Case-Control Studies Design Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes. Impaired glucose tolerance Diabetics Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fees & charges Female Health aspects Humans Hypoglycemic Agents - therapeutic use Insulin - analogs & derivatives Insulin - therapeutic use Insulin Glargine Insulin, Long-Acting Kinases Male Medical sciences Metabolic diseases Metformin Metformin - therapeutic use Middle Aged Miscellaneous Mortality Multivariate analysis Neoplasms - epidemiology Neoplasms - prevention & control Oncology, Experimental Original Research Pharmaceutical industry Public health. Hygiene Public health. Hygiene-occupational medicine Sulfonylurea Compounds - therapeutic use Teaching hospitals |
| title | Metformin and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T04%3A36%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metformin%20and%20Cancer%20Occurrence%20in%20Insulin-Treated%20Type%202%20Diabetic%20Patients&rft.jtitle=Diabetes%20care&rft.au=Monami,%20Matteo&rft.date=2011-01-01&rft.volume=34&rft.issue=1&rft.spage=129&rft.epage=131&rft.pages=129-131&rft.issn=0149-5992&rft.eissn=1935-5548&rft.coden=DICAD2&rft_id=info:doi/10.2337/dc10-1287&rft_dat=%3Cgale_pubme%3EA246253701%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=835075692&rft_id=info:pmid/20980415&rft_galeid=A246253701&rfr_iscdi=true |